PMID: 9420305Jan 7, 1998Paper

Clearance of an influenza A virus by CD4+ T cells is inefficient in the absence of B cells

Journal of Virology
D J Topham, P C Doherty

Abstract

The primary CD8+ T-cell response protected most B-cell-deficient muMT mice against intranasal infection with the HKx31 influenza A virus. Prior exposure did not prevent reinfection upon homologous challenge, and the recall CD8+ T-cell response cleared the virus from the lung within 7 days. Depleting the CD8+ T cells substantially reduced the capacity of these primed mice to deal with the infection, in spite of evidence for established CD4+ T-cell memory. Thus, the control of this relatively mild influenza virus by both primary and secondary CD4+ T-cell responses is relatively inefficient in the absence of B cells and CD8+ T cells.

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