PMID: 37164Apr 1, 1979

Clearance of bacteria from cerebrospinal fluid to blood in experimental meningitis

Infection and Immunity
W M ScheldM A Sande

Abstract

The occurrence and importance of secondary bacteremia in the pathogenesis of and response to therapy in meningitis is uncertain. Streptococcus pneumoniae type III was injected into the cerebrospinal fluid of the cisterna magna in anesthetized, curarized dogs, and sequential simultaneous samples were obtained from the superior sagittal sinus, cisterna magna, and peripheral blood. The results show that: (i) bacteria are rapidly transported from the cerebrospinal fluid to blood but only after active multiplication within the cerebrospinal fluid, and (ii) entrance into the blood from the cerebrospinal fluid occurs before the height of the febrile response or cerebrospinal fluid pleocytosis.

References

Aug 1, 1990·Neuropathology and Applied Neurobiology·A E Williams, W F Blakemore
Dec 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Uwe KoedelCarsten J Kirschning
Jan 26, 2000·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·M A Sande, M G Täuber
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tobias RupprechtUwe Koedel
Apr 30, 2004·Brain : a Journal of Neurology·Uwe KoedelCarsten J Kirschning

Related Concepts

Pathogenic Aspects
Blood - Brain Barrier Anatomy
Meningitis, Pneumococcal, Penicillin-Resistant
Pathogenesis
Peripheral Blood
Structure of Cisterna Magna
Cerebrospinal Fluid
Superior Sagittal Sinus
Entire Cisterna Magna
Bacteremia

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