Clearance of cyclopentyladenosine and cyclohexyladenosine in rats following a single subcutaneous dose

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Kai Tuovinen, Juhani Tarhanen

Abstract

A(1)-adenosine receptor agonist N(6)-cyclopentyladenosine (CPA) (3.0 mg kg(-1) body weight), or N(6)-cyclohexyladenosine (CHA) (3.0 mg kg(-1) body weight) was subcutaneously (s.c.) administered as a single dose to rats. After that, the blood samples (150 microl) were collected from vena saphena into heparinized capillary tubes at the different time points. The concentrations of CPA and CHA were assayed by reversed-phase high performance liquid chromatography (HPLC). Based on the present study, the retention times for CPA and CHA were 3.029 +/- 0.017 min and 5.07 +/- 0.031 min, respectively. In addition, the maximum concentrations of CPA and CHA were measured 60 and 80 min after the administration, and the half-lives of these compounds in the circulation were approximately 48.5 +/- 4.4 min and 106.6 +/- 7.4 min, respectively. Presumably, the difference between these values due to the larger cycloalkyl substituent of CHA and different absorption properties of these compounds. Moreover, in the present study, the elimination half-life was approximately sevenfold longer than that previously reported for CPA (48.5 +/- 4.4 min versus 6.9 +/- 0.5] min). The discrepancy in the half-life is not surprising because the administration route...Continue Reading

Citations

Feb 23, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Juliano Q D RodriguesRosely O Godinho
Jan 19, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michal HoferZuzana Hoferova
Jun 28, 2017·The Journal of Pharmacology and Experimental Therapeutics·Isaac R BaileyKelly L Drew

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