Jul 8, 1999

Clearance of glutamate inside the synapse and beyond

Current Opinion in Neurobiology
D E BerglesC E Jahr

Abstract

The heated debate over the level of postsynaptic receptor occupancy by transmitter has not been extinguished - indeed, new evidence is fanning the flames. Recent experiments using two-photon microscopy suggest that the concentration of glutamate in the synaptic cleft does not attain levels previously suggested. In contrast, recordings from glial cells and studies of extrasynaptic receptor activation indicate that significant quantities of glutamate escape from the cleft following exocytosis. Determining the amount of glutamate efflux from the synaptic cleft and the distance it diffuses is critical to issues of synaptic specificity and the induction of synaptic plasticity.

  • References43
  • Citations166

Mentioned in this Paper

Synaptic Cleft
Neurons
Neuroglia
End Plate Potentials
Synapses
Microscopy
Exocytosis
Glutamic Acid, (D)-Isomer
Potassium Glutamate
Glutamate

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