Clearance of HCV RNA following acute hepatitis A superinfection

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
B CacopardoL Nigro

Abstract

A transient reduction of hepatitis C virus replication during the course of acute hepatitis A virus infection has already been reported in the literature. The present study reports the case study of a subject with chronic hepatitis due to hepatitis C virus who went on to develop an acute hepatitis A. From the early onset of acute disease, hepatitis C virus ribonucleic acid became undetectable. Following recovery from acute hepatitis, alanine amino-transferase levels became persistently normal and liver biopsy revealed a reduction in the Knodell histological activity index score. Hepatitis C virus ribonucleic acid clearance was maintained up to 4 years after the onset of acute hepatitis A. During the course of the acute disease, a sharp increase in interferon gamma levels was detected in serum and in the supernatant of both unstimulated and phytoemagglutinin/lipopolysaccharide-stimulated peripheral blood mononuclear cells. Interferon gamma levels were still high 3 months later. We hypothesize that acute hepatitis A virus superinfection during the course of chronic hepatitis C may lead to hepatitis C virus ribonucleic acid clearance through an immunological mechanism related to interferon gamma production.

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Citations

Aug 24, 2012·Expert Review of Vaccines·Mélanie LambotinSamira Fafi-Kremer
Mar 25, 2011·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Hisham O Akbar
Oct 18, 2012·Journal of Medical Virology·Su Rin ShinMyung Seok Lee
Jan 2, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elisabeth LehmannGabriele Sass
Mar 19, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Francesca Mori UbaldiniMarina Nunez
Sep 6, 2020·International Journal of Molecular Sciences·Tatsuo KandaMitsuhiko Moriyama

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