Clearance of HSV-2 from recurrent genital lesions correlates with infiltration of HSV-specific cytotoxic T lymphocytes

The Journal of Clinical Investigation
David M KoelleL Corey

Abstract

The mechanisms involved in host clearance of symptomatic mucocutaneous herpes simplex virus (HSV) infection are unclear. We studied the functional properties of bulk cultures of skin-infiltrating lymphocytes from normal skin and serial biopsies of recurrent genital HSV-2 lesions, and compared HSV-specific and NK responses with viral clearance. HSV-specific CD4+ or CD8+ T cells were rarely detected in lymphocytes cultured from normal skin. The total lymphocyte count and HSV-specific and NK-like effector cell activities were markedly higher in cultures derived from lesional skin. HSV-specific CD4+ proliferative responses and NK-like cytotoxic responses were present at all stages of herpetic lesions, including biopsies early in the disease course. In contrast, cytotoxic T lymphocyte activity was generally low among cells derived from early culture-positive lesions, and increased during lesion evolution. Viral clearance from the lesion site was associated with a high level of local cytolytic activity towards HSV-infected cells. The phenotypes of cells with HSV-specific cytotoxic responses varied between patients, having CD4+ and CD8+ components. Immunotherapeutic approaches to HSV should be directed at improving in vivo cytolytic a...Continue Reading

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Citations

Apr 9, 1999·Vaccine·D I Bernstein, L R Stanberry
Aug 30, 2000·Microbes and Infection·S P DeshpandeB T Rouse
May 7, 2010·Immunology and Cell Biology·Anthony L CunninghamStuart Turville
Mar 8, 2013·Nature Medicine·Joshua T Schiffer, Lawrence Corey
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Aug 7, 2009·Journal of Virology·Amanda Kwant-MitchellKenneth L Rosenthal

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