Clearance of immunoreactive somatostatin by perfused rat liver

The Journal of Clinical Investigation
H Sacks, L C Terry

Abstract

Other investigators have demonstrated that concentrations of immunoreactive somatostatin (IRS) are higher in blood from the hepatic portal vein or its tributaries than in blood from the hepatic or peripheral systemic veins of man and animals. This suggests that there is hepatic extraction of IRS from the portal system in vivo. In the rat, portal vein plasma IRS is reported to be heterogeneous and to contain, in part, a 1,600 mol wt form of IRS which is immunochemically similar to synthetic somatostatin and not significantly bound to high molecular weight plasma protein. Our study was undertaken to determine directly whether unbound synthetic cyclic somatostatin was cleared by the rat liver perfused through the hepatic portal vein in vitro with a recirculating, plasma-free, erythrocyte-containing perfusate. At 37 degrees C and pH 7.40, perfusate IRS, at initial concentrations (1,728 pg/ml) within the range previously reported in rat portal venous blood, was removed by the liver at a rate commensurate with first-order kinetics. Hepatic clearance was 0.84+/-0.04 ml/min per g postperfusion wet weight (SE). Hepatic extraction was 36+/-2%, and t((1/2)) was 20.0+/-1.3 min. Recovery of IRS from the perfusate without the liver was >85%,...Continue Reading

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Mar 1, 1989·Digestive Diseases and Sciences·M R Lucey, T Yamada
Jan 26, 1987·Life Sciences·M M WolfeJ E McGuigan
Nov 1, 1983·Molecular and Cellular Endocrinology·E C Griffiths, J R McDermott
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