Clearance of myelin constituents and axonal sprouting in the transected postcommissural fornix of the adult rat

The European Journal of Neuroscience
C C StichelH W Müller

Abstract

Following transection of the postcommissural fornix in the adult rat, fibres retract from the lesion zone but then start to regrow within their former pathway up to the lesion site, where they terminate. The fibres neither penetrate nor bypass this region. In order to define the molecular mechanisms that cause regenerative failure at the lesion site, we analysed the spatiotemporal relationship between clearance/re-expression of myelin constituents and axon sprouting. Using immunocytochemical methods, we investigated the distribution of myelin-associated growth inhibitor (NI-35/250) and myelin basic protein after transection of the postcommissural fornix. In the studies described here we demonstrate the sequential removal of neurofilaments and myelin constituents in a perilesion zone and at the lesion site. The removal of myelin constituents was followed by the extensive regrowth of fornix fibres in the proximal segment. However, these fibres stopped at the lesion site, an area that lacked immunostaining for NI-35/250 and. In the distal stump we observed the disappearance of neurofilament along the entire fornix segment but spatial differences in the removal of myelin constituents. While both NI-35/250 and myelin basic protein d...Continue Reading

References

Aug 1, 1978·The Journal of Cell Biology·W W Schlaepfer, S Micko
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·E D LaywellD A Steindler
Jun 26, 1990·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·W L MaxwellM Berry
Jan 1, 1990·Experimental Brain Research·C C StichelK Zilles
Oct 1, 1987·The Journal of Experimental Medicine·V H Perry, S Gordon
Nov 24, 1987·Brain Research·J Miklossy, H Van der Loos
Jan 1, 1973·International Review of Cytology·H D Dellmann
Jan 1, 1984·Progress in Neurobiology·U J Zimmerman, W W Schlaepfer
Jun 10, 1982·Brain Research·P McConnell, M Berry
Jan 1, 1993·Annual Review of Neuroscience·M E SchwabC E Bandtlow
Jul 1, 1993·Trends in Neurosciences·V H PerryS Gordon
Oct 1, 1993·Experimental Neurology·J A BrodkeyD A Steindler
Aug 1, 1993·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J FrisénM Risling
May 8, 1994·The Journal of Comparative Neurology·T SivronM Schwartz
May 1, 1994·The European Journal of Neuroscience·I Dusart, M E Schwab
Sep 1, 1993·The European Journal of Neuroscience·L Schnell, M E Schwab

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Citations

Jul 12, 2003·Brain Research. Developmental Brain Research·Aziz Hafidi, Dimetrios Galifianakis
Jul 8, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S A Gilmore, T J Sims
Mar 3, 1999·The European Journal of Neuroscience·C C StichelH W Müller
Jun 12, 2002·Molecular and Cellular Neurosciences·Zhi Jiang ChenJoel M Levine
Oct 15, 1998·Molecular and Cellular Neurosciences·M LabesA Roach

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