Clearance of Pseudomonas aeruginosa from the murine gastrointestinal tract is effectively mediated by O-antigen-specific circulating antibodies.

Infection and Immunity
G B PierJ B Goldberg

Abstract

The colonization of mucosal surfaces by Pseudomonas aeruginosa can lead to local or disseminated disease. Secretory immunoglobulin A (IgA) has been assumed to be responsible for preventing mucosal colonization by interfering with the binding of bacterial ligands to epithelial surface receptors. However, the efficacy of this mechanism of immunity derives little actual support from in vivo experiments. In an investigation of the role of local and systemic immunization strategies in reducing colonization of the gastrointestinal tract of mice by P. aeruginosa, the bacterial antigens that were potential targets for immune effectors promoting mucosal clearance were identified. Levels of gastrointestinal colonization were reduced when immunity to homologous O antigens, but not that to pili or flagella, was elicited. Oral vaccination with attenuated Salmonella typhimurium expressing P. aeruginosa serogroup O11 antigen elicited mucosal and serum IgA antibodies and serum IgG antibodies specific for the recombinant antigen. Oral challenge of immunized mice with P. aeruginosa serogroup O11 demonstrated protection against gastrointestinal colonization. Intraperitoneal immunization with a serogroup O11 high-molecular-weight O-polysaccharide ...Continue Reading

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Citations

Jul 10, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sukumar SahaKenji Okuda
Sep 29, 2011·PLoS Pathogens·Rustin R LovewellBrent Berwin
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Antonio DiGiandomenicoJoanna B Goldberg
Dec 21, 2007·Clinical and Vaccine Immunology : CVI·Jennifer M Scarff, Joanna B Goldberg
Jan 28, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Rustin R LovewellBrent Berwin
Jan 10, 1998·Infection and Immunity·M FeldmanA Prince
Jul 10, 1999·Journal of Bacteriology·C R DeanJ B Goldberg
Jul 27, 2017·Journal of Basic Microbiology·Qiong LiuQing Liu
Oct 30, 2016·International Journal of Medical Microbiology : IJMM·Dacie R BridgeD Scott Merrell
Dec 1, 1996·Trends in Microbiology·J B Goldberg, G B Pler

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