PMID: 7540299Jun 1, 1995Paper

Clearance of serum PSA after open surgery for benign prostatic hypertrophy, radical cystectomy, and radical prostatectomy

The Prostate
F HaabL Boccon-Gibod

Abstract

To study the clearance of serum prostate-specific antigen (PSA) after several types of prostatic tissue ablation. Serum PSA levels were measured (YANG Proscheck ultrasensitive assay) just before surgery, immediately after specimen removal, then twice weekly for 5 weeks or until it was undetectable (< 0.05 ng/ml) in patients undergoing radical cystoprostatectomy for bladder cancer (n = 10), or radical prostatectomy for T1 T2 prostate cancer (n = 18) and daily for 6 days after open surgery for benign prostatic hypertrophy (BPH) (n = 10). Open enucleation for BPH: the immediately postoperative PSA level was 6 times its preoperative value. It decreased following a monoexponential curve with a very short half-life of 0.55 +/- 0.39 days, range (0.14-1.3), reaching a value lower than the preoperative level in all cases, except one by day 3. After radical cystoprostatectomy: the decrease of serum PSA is monoexponential with a half life of 1.92 +/- 1.2 days (0.57-4.24) reaching undetectable level (< 0.05 ng/ml) in all patients by day 21. After radical prostatectomy: 11/18 patients (61%) showed a one-component exponential decrease in PSA with a half-life of 2.5 +/- 1.33 days (range 0.97-4.6 days), and 7/18 showed a two-component exponent...Continue Reading

References

Oct 1, 1990·The Journal of Urology·D J LightnerL Moore
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Mar 1, 1968·American Journal of Clinical Pathology·J E McNeal
Jan 1, 1981·The Prostate·M C WangT M Chu
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Citations

May 12, 2005·Urologic Oncology·Dan LeiboviciYoram I Siegel
Dec 19, 2003·The Urologic Clinics of North America·Joel B Nelson, Herbert Lepor
Dec 21, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R AlmuftiB You
Aug 1, 1997·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·M LeinS A Loening
Feb 23, 2011·Journal of the American Dietetic Association·Kim RobienCheryl L Rock
Jan 1, 1996·The Prostate. Supplement·A W PartinH B Carter
Jun 14, 2003·Prostate Cancer and Prostatic Diseases·B J MartinW Rayford
Jan 11, 2003·American Journal of Clinical Pathology·Kristin R SwansonJ D Murray

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