PMID: 9178110May 1, 1997Paper

Clearance of sodium lauryl sulphate from the oral cavity

Journal of Clinical Periodontology
S Fakhry-SmithA Gaffar

Abstract

Sodium lauryl sulphate (SLS) is used in toothpaste and mouth rinses as an emulsifying and surface cleaning agent. SLS has been implicated in an increased incidence of oral irritation in subjects predisposed to recurrent aphthous stomatitis (RAU). Hence, the purpose of this study was to determine the levels of SLS found in the oral cavity following rinsing with an SLS containing mouth rinse and brushing with a SLS containing dentifrice. An analytical method to separate SLS from saliva and other complex systems was developed. The method used high performance liquid chromatography (HPLC) and detection performed using conductivity measurements. Standard curves with known concentrations showed a detection limit of less than 0.4 ug SLS/ml of fluid. 2 clinical studies were conducted to determine the amount of SLS retained in the mouth by a healthy population after rinsing or brushing with commercially available products. The results showed, after rinsing, that 96% of the available SLS from the rinse was recovered in the collected samples within 2 min. Similarly, after brushing, 86% of the SLS contained within the toothpaste was recovered from the collected samples within the first 10 min. These results showed that the amount of SLS re...Continue Reading

Citations

Apr 14, 1999·Periodontology 2000·T D Rees
Sep 26, 2003·American Journal of Clinical Dermatology·A Ross Kerr, Jonathan A Ship
Nov 7, 2002·Acta Odontologica Scandinavica·Irma RantanenEva Söderling
Sep 20, 2011·Reumatología clinica·Gabriel Riera Matute, Elena Riera Alonso
Jun 20, 2007·Experimental Dermatology·Evelyn NeppelbergAnne Christine Johannessen
Jan 5, 2006·Oral Diseases·S JurgeS R Porter
Mar 16, 2017·Dermatitis : Contact, Atopic, Occupational, Drug·Anton de Groot
Apr 3, 2015·Journal of Human Genetics·Suparat SrithawongWibhu Kutanan

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