Clearance of the high intestinal (18)F-FDG uptake associated with metformin after stopping the drug.

European Journal of Nuclear Medicine and Molecular Imaging
Tamer OzülkerTevfik Ozpaçaci

Abstract

This study was done to determine whether interruption of metformin before (18)F-FDG PET/CT imaging could prevent the increased (18)F-FDG uptake in the intestine caused by this drug. Included in the study were 41 patients with known type 2 diabetes mellitus who were referred to our department for evaluation of various neoplastic diseases. Patients underwent two (18)F-FDG PET/CT scans, the first while they were on metformin and the second after they had stopped metformin. They stopped metformin and did not take any other oral antidiabetic medication starting 3 days before the second study and their blood glucose level was regulated with insulin when necessary to keep it within the range 5.55-8.33 mmol/l. FDG uptake was graded visually according to a four-point scale and semiquantitatively by recording the maximum standardized uptake value (SUVmax) in different bowel segments. A paired-samples t-test method was used to determine whether there was a significant difference between SUVmax measurements and visual analysis scores of the metabolic activity of the bowel in the PET/CT scans before and after stopping metformin. Diffuse and intense (18)F-FDG uptake was observed in bowel segments of patients, and the activity in the colon wa...Continue Reading

References

Apr 1, 1992·British Journal of Pharmacology·C J BaileyC Day
Feb 1, 1991·The Journal of Pharmacy and Pharmacology·C Wilcock, C J Bailey
Jun 1, 1990·Biochemical Pharmacology·C Wilcock, C J Bailey
Jun 1, 1994·British Journal of Pharmacology·C J BaileyT Page
Jan 1, 1994·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·C Wilcock, C J Bailey
Feb 29, 1996·The New England Journal of Medicine·C J Bailey, R C Turner
Jan 27, 1998·Clinical Nuclear Medicine·F MiraldiG P Leisure
Dec 14, 1999·Clinical Nuclear Medicine·H JadvarG M Segall
Sep 6, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Eric GontierJean-Louis Alberini
Mar 18, 2008·Arquivos brasileiros de endocrinologia e metabologia·Augusto Cézar Santomauro JúniorRicardo Peres do Souto
Jun 6, 2008·Diabetologia·C J BaileyJ H B Scarpello
Oct 16, 2008·Current Protein & Peptide Science·Pascual Sanz
Jan 24, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Félix-Nicolas RoyChristian Cohade
Feb 27, 2009·Acta Physiologica·W Wang, K-L Guan

❮ Previous
Next ❯

Citations

Feb 5, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Peiman HabibollahiUmar Mahmood
Oct 1, 2013·Bone Marrow Transplantation·C Bodet-MilinM Mohty
Mar 22, 2014·Annals of Nuclear Medicine·Mehmet A OzguvenMustafa O Emer
Sep 7, 2012·Acta Oncologica·Heath D SkinnerThomas M Guerrero
Jul 18, 2014·PET Clinics·Frederick D Grant
Jul 5, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael LinDavid Abi-Hanna
Jul 18, 2014·PET Clinics·Katherine Zukotynski, Chun K Kim
May 10, 2011·Clinical Nuclear Medicine·Bohdan BybelWilliam D Leslie
May 7, 2011·Analytical and Bioanalytical Chemistry·Sebastian MarschallPeter E Andersen
Aug 8, 2014·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Devin W SteenkampSara Meibom
Aug 12, 2017·Nuclear Medicine Communications·Michael MorrisBahar Dasgeb
Aug 15, 2020·Inflammatory Bowel Diseases·Mariane Le FurPeter Caravan
May 21, 2020·Clinical Nuclear Medicine·Anna Margherita MaffioneFederica Matteucci
Aug 24, 2020·Pflügers Archiv : European journal of physiology·Hermann Koepsell
Aug 25, 2020·Nuclear Medicine and Molecular Imaging·Hyung Seok ChangYoung Hwan Kim
Aug 21, 2020·Annals of Nuclear Medicine·Nanno SchreuderEugène P van Puijenbroek
Apr 18, 2019·Scientific Reports·Olga HorakovaMartin Rossmeisl
Dec 19, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Christos SachpekidisAntonia Dimitrakopoulou-Strauss
Jan 5, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Michela MassolloGianmario Sambuceti
Dec 19, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Reza ValiRuth Lim
Jul 11, 2021·Journal of Nuclear Medicine Technology·Bahar Moasses-GhafariParham Geramifar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved