PMID: 6600395Jan 1, 1983Paper

Clearance rates and systemic effects of intravenously administered interleukin 2 (IL-2) containing preparations in human subjects

British Journal of Cancer
C BindonP Hersey

Abstract

The present study was designed to examine the feasibility of in vivo administration of interleukin 2 (IL-2) to induce cytotoxic cell activity against tumours in human subjects. IL-2 was prepared from blood leukocytes stimulated with phytohaemagglutinin (PHA) and partially purified by membrane chromatography to exclude PHA. Administration of different amounts of IL-2 in vivo to 2 patients with melanoma revealed that the initial level of IL-2 in the circulation was related to the dose given and had a half-life of approximately 22.5 minutes. The initial and subsequent levels of IL-2 were lower than that expected to occur from equilibration in plasma and extracellular fluid. This was not apparently due to inactivation by serum factors because fresh human serum had little effect in vitro on the induction of mitogenic or cytotoxic activity by IL-2. Spontaneous division of lymphocytes was increased following IL-2 administration and it is suggested that clearance of IL-2 in vivo may reflect, in part, absorption by activated lymphocytes in the circulation. Side effects noted shortly after administration of the partially-purified IL-2 preparations included transient pyrexia, hypoglycaemia, increased cortisol levels, lymphocytopenia and s...Continue Reading

Citations

Jan 1, 1989·Cancer Chemotherapy and Pharmacology·T IchidaF Ichida
Sep 15, 1984·International Journal of Cancer. Journal International Du Cancer·G PizzaF Corrado
Mar 1, 1988·JPEN. Journal of Parenteral and Enteral Nutrition·J J PomposelliB R Bistrian
Jan 23, 2016·Frontiers in Immunology·Minh N PhamJose Luis Vela
Oct 1, 2020·International Journal of Molecular Sciences·Masakazu Hamada, Yoshiaki Yura
Jan 1, 1991·Cancer Investigation·J E Kolitz, R Mertelsmann
Jun 1, 1989·Immunological Investigations·J D FleischmannA L Imbembo
Aug 1, 1984·The Australian and New Zealand Journal of Surgery·P Hersey, C M Balch
Dec 14, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Juan DingJohn J Kopchick
Apr 18, 2015·Nature Reviews. Immunology·David Klatzmann, Abul K Abbas
Feb 10, 2017·Clinical Pharmacology and Therapeutics·T YuraszeckJ E Benjamin
Jul 6, 2017·Current Opinion in Oncology·María J de Miguel-LukenEmiliano Calvo
Feb 1, 1986·European Journal of Immunology·H KolbU Kiesel
Aug 24, 1999·Medical Oncology·P JantscheffC Rochlitz
Apr 12, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dominique MusselmanAndrew H Miller
Aug 2, 2011·Nature Reviews. Drug Discovery·W Joost LesterhuisCornelis J A Punt
Apr 1, 1985·Australian and New Zealand Journal of Medicine·D S Nelson, C L Geczy
Nov 1, 1989·Journal of Neurosurgery·T YamasakiM Hanaoka
Jul 1, 1997·Psychoneuroendocrinology·D Hinze-SelchY Zhang
Nov 1, 1995·Brain Research. Brain Research Reviews·U K Hanisch, R Quirion

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.