PMID: 8593304Oct 1, 1995Paper

Cleavability of hemagglutinin from an extremely virulent strain of avian influenza virus containing a unique cleavage site sequence

The Journal of Veterinary Medical Science
T HorimotoY Kawaoka

Abstract

An avian influenza virus, A/turkey/England/50-92/91 (H5N1), showed extremely high virulence in chickens, although its hemagglutinin (HA) cleavage site sequence (R-K-R-K-T-R), having a nonbasic (Thr) residue at the second position (P-2) from the carboxyl terminus of HA1, does not conform to the previously established consensus sequence motif, X-X-R/K-X-R/K-R (X = nonbasic residue), for highly virulent phenotype of the H5 virus. When we evaluated the HA cleavability of this strain in chicken embryo fibroblast culture, we observed that, unlike other HAs with a Thr residue at P-2, this HA was efficiently cleaved. These findings suggest that a nonbasic residue at the P-2 does not affect its recognition and catalyzation by cleavage enzymes that are otherwise influenced by steric structure around the cleavage site.

Citations

Mar 23, 2011·Virology Journal·Trong WisedchanwetAlongkorn Amonsin
Sep 28, 2007·Avian Pathology : Journal of the W.V.P.A·Brandon Z LondtDennis J Alexander
Sep 25, 2007·Comparative Immunology, Microbiology and Infectious Diseases·Thierry van den BergMichel Bublot
Sep 6, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Haibo WuNanping Wu
Dec 3, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Haibo WuNanping Wu
Jun 1, 2016·The Veterinary Journal·Masatoshi OkamatsuYoshihiro Sakoda
Dec 3, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Zhaobin FanHualan Chen
Jan 10, 2002·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R J Webby, R G Webster
Apr 9, 2020·Transboundary and Emerging Diseases·Yulei LiYanbing Li
Jul 29, 2017·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Haibo WuNanping Wu
Mar 14, 1998·Virus Research·M GarcíaM L Perdue
Aug 9, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Fan YangHaibo Wu

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