Cleavable and thermo-responsive hybrid nanoparticles for on-demand drug delivery

Journal of Colloid and Interface Science
Isabel Ortiz de SolorzanoManuel Arruebo

Abstract

By combining the photothermal ability of copper sulphide nanoparticles (NPs) upon excitation with Near Infrared (NIR) Light and the thermo-responsive properties of the homemade oligo (ethylene glycol) methyl ether methacrylate copolymer we have obtained fragmentable nanocomposites able to release a carried drug on-demand after NIR-light triggering. A complete physico-chemical characterization of the resulting nanoparticles has been carried out and their degradation assessed at different temperatures. Herein, we have also evaluated the drug loading capacity of those nanoparticles and the temperature dependence in their drug release kinetics using bupivacaine hydrochloride as a model drug. For those hybrid nanoparticles, subcytotoxic doses on four different cell lines and their potential interference in cell metabolism, induction of apoptosis, and cell cycle have been evaluated by Alamar Blue fluorometry and flow cytometry.

Citations

Nov 28, 2019·Nanomedicine·Isabel Ortiz de SolorzanoManuel Arruebo
Mar 3, 2020·Expert Opinion on Drug Delivery·Gracia Mendoza, Manuel Arruebo
Nov 15, 2019·Soft Matter·Micaela A MacchioneMiriam C Strumia
Jun 27, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Jessica F LiuAndrew Tsourkas
Aug 3, 2019·Journal of Functional Biomaterials·Carlos M WellsJ Amber Jennings
Oct 28, 2018·Journal of Colloid and Interface Science·Anda Mihaela CraciunLuminita Marin
Apr 7, 2021·ACS Applied Materials & Interfaces·Teresa AlejoManuel Arruebo
May 29, 2021·International Journal of Nanomedicine·Sasmita SamalMamoni Dash
Jul 31, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Carlos GarinAntonio Rezusta

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