Cleavage of amyloid beta peptide during constitutive processing of its precursor

Science
F EschP J Ward

Abstract

The amyloid beta peptide (A beta P) is a small fragment of the much larger, broadly distributed amyloid precursor protein (APP). Abundant A beta P deposition in the brains of patients with Alzheimer's disease suggests that altered APP processing may represent a key pathogenic event. Direct protein structural analyses showed that constitutive processing in human embryonic kidney 293 cells cleaves APP in the interior of the A beta P, thus preventing A beta P deposition. A deficiency of this processing event may ultimately prove to be the etiological event in Alzheimer's disease that gives rise to senile plaque formation.

References

Nov 30, 1989·Biochemical and Biophysical Research Communications·M R PalmertS G Younkin
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D SchubertG Cole
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M R PalmertS G Younkin
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·N K RobakisH M Wisniewski
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D J SelkoeT Oltersdorf
Jan 1, 1984·Hoppe-Seyler's Zeitschrift für physiologische Chemie·W Rautenberg, H Tschesche

❮ Previous
Next ❯

Citations

Nov 1, 1996·Journal of Neuroscience Research·P A PaganettiM Staufenbiel
Mar 1, 1997·Medicinal Research Reviews·J Pallarés-TrujilloJ M Argilés
Nov 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·F Crawford, A Goate
Jul 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R A Crowther
Jun 8, 2001·International Journal of Cancer. Journal International Du Cancer·S J WilliamsT M Antalis
Sep 1, 1992·Journal of Neuroscience Research·B WolozinT Sunderland
Oct 1, 1992·Journal of Neuroscience Research·K SambamurtiN K Robakis
Mar 1, 1994·Journal of Neuroscience Research·B D Trapp, P E Hauer
Apr 15, 1994·Journal of Neuroscience Research·J R CiallellaJ P McGillis
Apr 15, 1994·Journal of Neuroscience Research·D K LahiriM R Farlow
Oct 1, 1994·Journal of Neuroscience Research·J A RipellinoN K Robakis
Nov 1, 1994·Journal of Neuroscience Research·D NeillD Allsop
Feb 1, 1995·Journal of Neuroscience Research·B ZhaoJ W Kusiak
Jul 1, 1993·Medicinal Research Reviews·M WilliamsG L Neil
Nov 1, 1992·Journal of Neurobiology·D L PriceL C Cork
Mar 1, 1995·Journal of Peptide Science : an Official Publication of the European Peptide Society·G EvinC L Masters
Jan 1, 1994·Acta Neuropathologica·I R Mackenzie, L A Miller
Jan 1, 1994·Acta Neuropathologica·I R Mackenzie
Jan 1, 1993·Journal of Neural Transmission. General Section·A M Palmer, S T DeKosky
Mar 1, 1994·Metabolic Brain Disease·A LeBlanc
Jan 1, 1996·European Archives of Psychiatry and Clinical Neuroscience·C Haass
Jan 1, 1995·Journal of Molecular Neuroscience : MN·B UrmoneitT Dyrks

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.