Cleavage of high-molecular-weight kininogen by elastase and tryptase is inhibited by ferritin

American Journal of Physiology. Lung Cellular and Molecular Physiology
Lan G CoffmanSuzy V Torti

Abstract

Ferritin is a protein principally known for its role in iron storage. We have previously shown that ferritin can bind high-molecular-weight kininogen (HK). Upon proteolytic cleavage by the protease kallikrein, HK releases the proinflammatory peptide bradykinin (BK) and other biologically active products, such as two-chain high-molecular-weight kininogen, HKa. At inflammatory sites, HK is oxidized, which renders it a poor substrate for kallikrein. However, oxidized HK remains a good substrate for elastase and tryptase, thereby providing an alternative cleavage mechanism for HK during inflammation. Here we report that ferritin can retard the cleavage of both native HK and oxidized HK by elastase and tryptase. Initial rates of cleavage were reduced 45-75% in the presence of ferritin. Ferritin is not a substrate for elastase or tryptase and does not interfere with the ability of either protease to digest a synthetic substrate, suggesting that ferritin may impede HK cleavage through direct interaction with HK. Immunoprecipitation and solid phase binding studies reveal that ferritin and HK bind directly with a Kd of 134 nM. To test whether ferritin regulates HK cleavage in vivo, we used THP-1 cells, a human monocyte/macrophage cell l...Continue Reading

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Citations

Jul 31, 2013·Biochimica Et Biophysica Acta·Ahmed A Alkhateeb, James R Connor
Jan 8, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lan G CoffmanSuzy V Torti
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Proceedings of the National Academy of Sciences of the United States of America
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