Cleavage of membrane-bound CD40 ligand is not required for inducing B cell proliferation and differentiation

European Journal of Immunology
F PietravalleJ F Gauchat

Abstract

The physical interaction between the B cell surface molecule CD40 and its ligand, CD40L, is known to be crucial in the development and maintenance of humoral immunity. Recently it has been shown that the CD40L is processed and that its soluble cleavage products are released into the extracellular environment. To study the functions of soluble and membrane-bound human CD40L on human B cells, we generated an uncleavable CD40L cDNA deletion mutant. The activities of transfectants expressing either mutated or wild-type CD40L were then compared on human B cells. Both the soluble and the uncleavable membrane-bound CD40L were able to induce, in conjunction with interleukin-4, B cell proliferation and IgE synthesis. Therefore, membrane-bound and soluble CD40L exhibit the same pattern of activities on B cells and membrane CD40L cleavage is not a prerequisite for its function.

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Citations

Apr 1, 1998·European Journal of Immunology·M WykesD Gray
Jan 14, 1998·Nature Medicine·M TanakaS Nagata
Apr 5, 2000·The Journal of Experimental Medicine·A M HohlbaumA Marshak-Rothstein
Jan 19, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·K M el-ShamiL Eisenbach
Apr 4, 2002·Biological Chemistry·Persio Dello Sbarba, Elisabetta Rovida
Dec 5, 2006·Anais Da Academia Brasileira De Ciências·André L S SantosClaudia M D'Avila-Levy
Dec 1, 2020·Expert Review of Vaccines·Taylor SicardJean-Philippe Julien
Mar 26, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Suzanne SaltiWalid Mourad

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