Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis
Nature
Oct 11, 2019
Kim NewtonVishva M. Dixit
PMID: 31511692
Get paper from
Abstract
The aspartate-specific cysteine protease caspase-8 suppresses necroptotic cell death mediated by RIPK3 and MLKL. Indeed, mice that lack caspase-8 die in a RIPK3- and MLKL-dependent manner during embryogenesis1-3. In humans, caspase-8 deficiency is associated with immunodeficiency4 or ve...read more
Mentioned in this Paper
Cell Death
Cessation of Life
Egg Yolk (Dietary)
Embryo
Laboratory mice
Apoptosis
Endothelial Cells
Tumor necrosis factor receptor 1A
Caspase-3
RIPK1 protein, human
18
72
Paper Details
References
- References
- Citations
References currently unavailable
We're still populating references for this paper, please check back later.
- References
- Citations
No citations available
This paper may not have been cited yet.
Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis
Abstract
The aspartate-specific cysteine protease caspase-8 suppresses necroptotic cell death mediated by RIPK3 and MLKL. Indeed, mice that lack caspase-8 die in a RIPK3- and MLKL-dependent manner during embryogenesis1-3. In humans, caspase-8 deficiency is associated with immunodeficiency4 or ve...read more
Mentioned in this Paper
Cell Death
Cessation of Life
Egg Yolk (Dietary)
Embryo
Laboratory mice
18
72
Paper Details
References
- References
- Citations
References currently unavailable
We're still populating references for this paper, please check back later.
- References
- Citations
No citations available
This paper may not have been cited yet.
Get paper from