journal cover

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

Nature

Oct 11, 2019

Kim NewtonVishva M. Dixit

Get paper from

Abstract

The aspartate-specific cysteine protease caspase-8 suppresses necroptotic cell death mediated by RIPK3 and MLKL. Indeed, mice that lack caspase-8 die in a RIPK3- and MLKL-dependent manner during embryogenesis1-3. In humans, caspase-8 deficiency is associated with immunodeficiency4 or ve...read more

Mentioned in this Paper

Cell Death
Cessation of Life
Egg Yolk (Dietary)
Embryo
Laboratory mice
Apoptosis
Endothelial Cells
Tumor necrosis factor receptor 1A
Caspase-3
RIPK1 protein, human
18
72
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

Nature

Oct 11, 2019

Kim NewtonVishva M. Dixit

PMID: 31511692

DOI: 10.1038/s41586-019-1548-x

Abstract

The aspartate-specific cysteine protease caspase-8 suppresses necroptotic cell death mediated by RIPK3 and MLKL. Indeed, mice that lack caspase-8 die in a RIPK3- and MLKL-dependent manner during embryogenesis1-3. In humans, caspase-8 deficiency is associated with immunodeficiency4 or ve...read more

Mentioned in this Paper

Cell Death
Cessation of Life
Egg Yolk (Dietary)
Embryo
Laboratory mice
18
72
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Get paper from

/papers/cleavage-of-ripk1-by-caspase-8-is-crucial-for/31511692