Cleavage of the N-linked oligosaccharide from the surfaces of Chlamydia species affects infectivity in the mouse model of lung infection.

Infection and Immunity
Lee Ann CampbellCho-Chou Kuo

Abstract

Previous studies determined that the Chlamydia glycan contains a high-mannose oligosaccharide, which is involved in attachment and infectivity of the organism, and that removal of the glycan decreases infectivity in vitro. The present study demonstrates that treatment of the organism with N-glycanase decreases or ablates infectivity in vivo.

References

May 29, 1992·Cell·J P Zhang, R S Stephens
Aug 1, 1989·Infection and Immunity·P B WyrickC R Bagnell
Apr 1, 1997·The Journal of Infectious Diseases·T C MoazedL A Campbell

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Citations

Mar 12, 2008·Antimicrobial Agents and Chemotherapy·Lee Ann CampbellDavid M Rothstein
Sep 8, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Juan Pablo Mackern-ObertiVirginia Elena Rivero
Dec 28, 2019·International Journal of Molecular Sciences·Liam Caven, Rey A Carabeo
Sep 26, 2020·Frontiers in Immunology·Diyoly AyonaBenoit Desnues

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