Cleave but not leave: Astrotactin proteins in development and disease

IUBMB Life
Hao Chang

Abstract

Over the years, animal studies have identified astrotactins as important membrane proteins for glial-guided neuronal migration during central nervous system development and hair follicle polarity control during skin development. Biochemical studies have revealed intramembrane proteolysis as an important feature of astrotactins. The two fragments of astrotactins remain linked together by a disulfide bond after the proteolytic cleavage. In humans, mutations in astrotactin genes have also been linked to a wide range of diseases, including several developmental brain disorders, neurodegenerative diseases and cancer. In this review, I will summarize the current knowledge of the biological function of astrotactins in development, highlight the linkage between mutations in astrotactin genes and human disease and discuss several outstanding questions that remain unanswered. © 2017 IUBMB Life, 69(8):572-577, 2017.

References

Jan 1, 1988·Annual Review of Neuroscience·R W Williams, K Herrup
Jun 1, 1995·Neuropediatrics·W B Dobyns, C L Truwit
Apr 15, 1999·Annual Review of Neuroscience·M E Hatten
May 23, 2002·Developmental Cell·Paul N Adler
May 2, 2003·Nature·Mireille MontcouquiolMatthew W Kelley
Jun 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nini GuoJeremy Nathans
Feb 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yanshu WangJeremy Nathans
Jan 30, 2007·Development·Yanshu Wang, Jeremy Nathans
Mar 23, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael R DeansLisa V Goodrich
Apr 10, 2009·The Journal of Investigative Dermatology·Aurélia RavniFadel Tissir
May 1, 2009·Nature·Joseph T GlessnerHakon Hakonarson
May 12, 2009·Seminars in Cell & Developmental Biology·Todd E GoldeDoron C Greenbaum
Jun 25, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Perrin M WilsonMary E Hatten
Sep 14, 2010·Protein Science : a Publication of the Protein Society·Gu Chen, Xu Zhang
Oct 21, 2010·Current Topics in Developmental Biology·Andreas Jenny
Nov 3, 2010·Neuropsychology Review·Joan Stiles, Terry L Jernigan
Jan 12, 2011·Current Neurology and Neuroscience Reports·Judy S Liu
Apr 28, 2011·Development·Lisa V Goodrich, David Strutt
Jul 12, 2011·Nature Cell Biology·Danelle DevenportElaine Fuchs
Nov 1, 2011·Genome Biology·Sinisa Urban, Seth W Dickey
Nov 6, 2012·Current Biology : CB·Eszter K VladarJeffrey D Axelrod
Feb 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Hao Chang, Jeremy Nathans
Oct 9, 2013·Biochimica Et Biophysica Acta·Nathalie Jurisch-YaksiWim Annaert
Oct 9, 2013·Biochimica Et Biophysica Acta·Matthias VossRegina Fluhrer
May 7, 2014·Sub-cellular Biochemistry·Gregor AnderluhRobert J C Gilbert
Jul 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Camille BoutinFadel Tissir
Nov 21, 2014·Journal of Neural Transmission·Ke-Sheng WangChun Xu
Apr 8, 2015·PloS One·Shijia HuJohn Timothy Wright
May 6, 2015·Trends in Biochemical Sciences·D LangoschM K Lemberg
Nov 5, 2015·Physiological Genomics·Allen W CowleyMingyu Liang
May 4, 2016·Journal of Neural Transmission·Christine M FreitagAndreas Reif
May 8, 2016·Mechanisms of Development·Dongbo ShiToshihiko Fujimori
Jan 20, 2017·The Journal of Biological Chemistry·Hao ChangJeremy Nathans

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Citations

Apr 18, 2018·Developmental Neurobiology·Michal KielbinskiKrzysztof Janeczko
Jun 7, 2019·Chembiochem : a European Journal of Chemical Biology·Hisaaki HiroseHiroaki Suga
Aug 20, 2021·Psychiatric Genetics·Alessia BauleoElena Falcone

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