CLEC-38, a transmembrane protein with C-type lectin-like domains, negatively regulates UNC-40-mediated axon outgrowth and promotes presynaptic development in Caenorhabditis elegans.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Gauri KulkarniW G Wadsworth

Abstract

In the developing nervous system, axons respond to various guidance cues to find their targets. The effects guidance cues have on an axon may change as an axon undergoes morphological changes, such as branching, turning, and synapse formation. The means by which these changes are regulated are not well understood. In Caenorhabditis elegans, the UNC-40/DCC (deleted in colorectal cancer) receptor mediates responses to the UNC-6/netrin guidance cue. Here, we show that CLEC-38, a protein with predicted transmembrane and C-type lectin-like domains, regulates UNC-40-mediated axon outgrowth as well as the organization of presynaptic terminals. We observe that, in genetic backgrounds sensitized for axon guidance defects, loss of clec-38 function can suppress defects in an UNC-40-dependent manner. Within migrating axons, clec-38 acts cell autonomously. Furthermore, loss of clec-38 function alters UNC-40::GFP (green fluorescent protein) expression. We also observe that loss of clec-38 function disrupts presynaptic patterning in animals with normal axon guidance and that there are genetic interactions between clec-38 and rpm-1, which encodes a protein implicated in regulating presynaptic assembly and axon morphology. We suggest CLEC-38 pl...Continue Reading

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Citations

Jun 15, 2011·Neural Development·Joori ParkMiri Kerensa Vanhoven
Oct 28, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sarah C PetersenDavid M Miller
Aug 10, 2010·Biological Psychiatry·Kanchana JagannathanGodfrey D Pearlson
Oct 28, 2008·Trends in Cell Biology·Christopher C Quinn, William G Wadsworth
Oct 14, 2008·Biochemical and Biophysical Research Communications·Tomoharu TakeuchiKen-ichi Kasai
Mar 30, 2011·Developmental Biology·Ahmed M Mohamed, Ian D Chin-Sang
Jan 24, 2017·Genetics·Andrew D ChisholmWilliam G Wadsworth

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