Cleft Alveolus Reconstruction Using a Three-Dimensional Printed Bioresorbable Scaffold With Human Bone Marrow Cells

The Journal of Craniofacial Surgery
Geunseon AhnUi-Lyong Lee

Abstract

Bone tissue engineering technology based on scaffold has been applied for cleft lip and palate treatment. However, clinical applications of patient-specific three-dimensional (3D) scaffolds have rarely been performed. In this study, a clinical case using patient-specific 3D-printed bioresorbable scaffold with bone marrow stromal cells collected from iliac crest in the operating room has been introduced. At 6-month after transplantation, the bone volume of the newly regenerated bone was approximately 45% of the total defect volume. Bone mineral density of the newly regenerated bone was about 75% compared to the surrounding bone. The Hounsfield unit value was higher than that of cancellous maxillary alveolar bone and lower than that of the cortical maxillary alveolar bone. Bone-marrow-derived mesenchymal stem cells-seeded 3D-printed patient-specific polycaprolactone scaffolds offer a promising alternative for alveolar cleft reconstruction and other bony defects.

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Citations

Aug 17, 2020·The Journal of Craniofacial Surgery·Shuaishuai WeiLinzhong Wan
Aug 28, 2020·Tissue Engineering. Part a·Chen ShenSimon Young
Apr 10, 2020·Frontiers in Bioengineering and Biotechnology·Paula KornMichael Gelinsky
Jan 11, 2020·Frontiers in Cell and Developmental Biology·Katiúcia Batista Silva PaivaAriadne Letra
May 8, 2021·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Farrukh R ViraniCraig W Senders
May 11, 2021·Plastic and Reconstructive Surgery. Global Open·Alex Q LynnChad M Teven

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