Cleft lip and palate in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin: a morphological in vivo study

Congenital Anomalies
Tomohiro YamadaToshio Sugahara

Abstract

It is well-known that TCDD (2,3,7,8, tetrachloridedibenzo-p-dioxin) induces cleft palates (CPs) in pregnant C57BL mice. However, it is unclear if TCDD is a possible teratogen for cleft lip. We examined maxillofacial malformations including cleft lip in three animal strains: A/J mice, C57BL/6J mice and ICR mice. The A/J mouse develops cleft lip and palate spontaneously at a 5-10% rate. TCDD was administered in olive oil on gestation day (GD) 12.5 with gastric tubes at 10 microg/kg, 20 microg/kg, or 40 microg/kg to examine the dose-response, and on a single day from GD 8.5-14.5 to examine the timing effects of TCDD administration on lip and palate formation. Furthermore, the palatal shelf movements during GD 8.5-14.5 were observed with a stereoscopic microscope. All embryos had cleft palates when the TCDD was administered just before palatogenesis (GD11.5-GD12.5). With respect to the TCDD effects, there were large differences among the strains. In the A/J mice, the difference between a lethal dose and a dose that could induce a cleft palate was close. Cleft lips were not induced, even when the TCDD was given just before labiogenesis. Morphologically, both palatal shelves contacted perfectly along their lengths, but separated and ...Continue Reading

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Citations

Apr 23, 2013·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Tomohiro YamadaTetsuya Yamamoto
Sep 13, 2014·Otolaryngologic Clinics of North America·Larry D Hartzell, Lauren A Kilpatrick
Aug 26, 2014·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Nesrine Z MostafaReena Talwar
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Jun 18, 2016·Toxicology and Applied Pharmacology·Zhan GaoZengli Yu
Mar 29, 2016·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Xingang YuanYuexian Fu
Dec 18, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Terry C HrubecSteven D Holladay
Jun 11, 2016·Experimental and Therapeutic Medicine·Liyun GaoWeidong Wu
May 23, 2020·Plastic and Reconstructive Surgery. Global Open·Marie NaudotSophie Le Ricousse
Feb 3, 2019·International Journal of Molecular Sciences·Wataru Yoshioka, Chiharu Tohyama
Aug 20, 2020·In Vitro Cellular & Developmental Biology. Animal·Yuichi MineMiho K Furue
Oct 31, 2020·Birth Defects Research·Michael A GarlandChengji J Zhou
Aug 18, 2020·Mutation Research. Reviews in Mutation Research·Bianca Domit Werner LinnenkampRoberto Hirochi Herai

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