Abstract
Cleft lip and/or cleft palate (CLP) is the most common major congenital malformation of the head and neck. Previous studies suggested an association between fetal opioid exposure and CLP. This study seeks to evaluate the associations between CLP and neonatal abstinence syndrome (NAS) in the United States. Population-based inpatient registry analysis. Academic medical center. Kids' Inpatient Database (2016) was used to identify weighted in-hospital births with diagnoses of CLP or NAS. Demographic information was obtained. Among 3.8 million weighted in-hospital births, prevalence rates of CLP in the NAS and non-NAS populations were 3.13 and 1.35 per 1000, respectively. The odds ratios for patients with NAS developing CLP, isolated cleft palate, isolated cleft lip, and cleft lip and palate when compared with the reference population were 2.33 (95% CI, 1.87-2.91; P < .001), 4.97 (95% CI, 3.84-6.43; P < .001), 1.01 (P = .98), and 0.80 (P = .46). Independent predictors of CLP within the NAS population included median household income for patients' zip code, race, hospital region, payment method, and maternal use of tobacco or other drugs of addiction. The binary logistic regression model accounting for possible confounding variables ...Continue Reading
References
Jan 1, 1975·Acta Odontologica Scandinavica·I Saxén
Mar 1, 1975·International Journal of Epidemiology·I Saxén
Oct 1, 1995·Journal of Paediatrics and Child Health·D B Thomas
May 1, 1996·Archives of Disease in Childhood. Fetal and Neonatal Edition·M TenenbeinV D Debooy
May 21, 2004·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Elisa CalzolariUNKNOWN EUROCAT Working Group
Feb 9, 2007·American Journal of Medical Genetics. Part a·Elisa CalzolariFrancesca Rivieri
Nov 23, 2007·Annual Review of Public Health·Helen Levy, David Meltzer
Sep 15, 2009·Lancet·Peter A MosseyWilliam C Shaw
Feb 27, 2013·Pediatrics·Marylou BehnkeUNKNOWN Committee on Fetus and Newborn
Jul 31, 2013·Journal of the American College of Surgeons·Garth H UtterPatrick S Romano
Jul 30, 2014·Pediatrics·Prabhakar Kocherlakota
Nov 18, 2014·Birth Defects Research. Part A, Clinical and Molecular Teratology·Cara T MaiUNKNOWN National Birth Defects Prevention Network
Dec 3, 2014·Facial Plastic Surgery Clinics of North America·David J Crockett, Steven L Goudy
Jan 27, 2015·Journal of Addiction Medicine·Marjorie C MeyerSarah H Heil
May 31, 2016·F1000Research·Ariadna Forray
Aug 12, 2016·MMWR. Morbidity and Mortality Weekly Report·Jean Y KoWanda D Barfield
Dec 22, 2016·The New England Journal of Medicine·Karen McQueen, Jodie Murphy-Oikonen
Jun 1, 2017·Pediatrics·Jennifer N LindCheryl S Broussard
Apr 4, 2018·JAMA : the Journal of the American Medical Association·Elisha M WachmanMichael Silverstein
Mar 13, 2019·Plastic and Reconstructive Surgery. Global Open·Cody L MullensA Corde Mason
Feb 6, 2020·Nature Methods·Pauli VirtanenUNKNOWN SciPy 1.0 Contributors
Citations
Mar 24, 2021·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jennifer N ShehanJessica R Levi
May 13, 2021·The Annals of Otology, Rhinology, and Laryngology·Jennifer N ShehanJessica R Levi
Oct 2, 2021·The Annals of Otology, Rhinology, and Laryngology·Elizabeth J AbrahamJessica R Levi