PMID: 11922437Apr 2, 2002Paper

Cleft of the mitral valve in patients with Down's syndrome

Cardiology in the Young
Alain FraisseJ Kachaner

Abstract

Differentiation between a cleft of the mitral valve and the cleft of the left side of an atrioventricular septal defect--a lesion commonly found in patients with Down's syndrome--is surgically important since the distribution of the conduction tissue varies between the 2 lesions. We sought to determine if cleft of the mitral valve occurs also in patients with Down's syndrome. We studied 5 patients with Down's syndrome and cleft of the mitral valve followed in our institution. Echocardiography showed in all 5 patients a cleft dividing the anterior (aortic) leaflet of mitral valve with normal papillary muscle position, mural leaflet size, and ratio of the inlet/outlet dimension of the left ventricle. Associated cardiac lesions were present in all 5 patients: perimembranous ventricular septal defect in 3, ostium secundum atrial septal defect in 2 and patent ductus arteriosus in 2 patients. During the 5.6 years (0.2-11) of the follow-up period, surgical repair of the cleft was never indicated since the mitral regurgitation through the cleft remained mild or absent in all the patients. Two patients underwent closure of a ventricular septal defect, with atrial septal defect closure in one and ductal ligation in 2. One patient died su...Continue Reading

Citations

Jun 19, 2010·Cardiovascular Research·Louisa DunlevyTimothy Mohun
Jul 25, 2003·Asian Cardiovascular & Thoracic Annals·Kaan KiraliCevat Yakut
Oct 21, 2015·Pediatric Cardiology·Poonam P Thankavel, Claudio Ramaciotti

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