Click-click chemistry on a peptidic scaffold for easy access to tetrameric DNA structures

Chemical Communications : Chem Comm
Romaric BonnetEric Defrancq

Abstract

The use of a peptidic template and orthogonal oxime ligation and CuAAC reaction allows a stepwise approach for the design of antiparallel tetrameric DNA structure. As a proof of concept template assisted synthesis of i-motif DNA was achieved. As anticipated, a dramatic improvement in the stability of such a tetrameric structure was observed. More interestingly the formation of the i-motif was still observed at neutral pH, which could be attributed to the spatial proximity of the basic centers.

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Citations

Nov 24, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna AviñóRamon Eritja
Feb 20, 2015·Chemical Communications : Chem Comm·Romaric BonnetEric Defrancq
Dec 25, 2013·Beilstein Journal of Organic Chemistry·Regina Berg, Bernd F Straub
Jun 10, 2014·Chemical Communications : Chem Comm·P N Asare-OkaiM Royzen
Mar 11, 2015·Biopolymers·Jeannette E MarineJonathan G Rudick
Jul 6, 2014·Chemical Society Reviews·Wen Tang, Matthew L Becker
Aug 7, 2020·Organic & Biomolecular Chemistry·Alexandre DevauxEric Defrancq

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