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Click-Particle Display for Base-Modified Aptamer Discovery

ACS Chemical Biology

Oct 12, 2019

Chelsea K. L. GordonHyongsok Tom Soh

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Abstract

Base-modified aptamers that incorporate non-natural chemical moieties can achieve greatly improved affinity and specificity relative to natural DNA or RNA aptamers. However, conventional methods for generating base-modified aptamers require considerable expertise and resources. In this ...read more

Mentioned in this Paper

Concanavalin A
Operant Conditioning
DNA
Epinephrine
Lectin
Fluorescence-Activated Cell Sorting
Chemicals
Inhibitors
Aptamer
Reporting
6
16
Paper Details
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Click-Particle Display for Base-Modified Aptamer Discovery

ACS Chemical Biology

Oct 12, 2019

Chelsea K. L. GordonHyongsok Tom Soh

PMID: 31532184

DOI: 10.1021/acschembio.9b00587

Abstract

Base-modified aptamers that incorporate non-natural chemical moieties can achieve greatly improved affinity and specificity relative to natural DNA or RNA aptamers. However, conventional methods for generating base-modified aptamers require considerable expertise and resources. In this ...read more

Mentioned in this Paper

Concanavalin A
Operant Conditioning
DNA
Epinephrine
Lectin
6
16
Paper Details
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    We're still populating references for this paper, please check back later.
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