Click with a boronic acid handle: a neighboring group-assisted click reaction that allows ready secondary functionalization

Chemical Communications : Chem Comm
Alexander Boryanov DraganovBinghe Wang

Abstract

The feasibility of a neighboring boronic acid-facilitated facile condensation of an aldehyde is described. This reaction is bio-orthogonal, complete at room temperature within minutes, and suitable for bioconjugation chemistry. The boronic acid group serves the dual purpose of catalyzing the condensation reaction and being a handle for secondary functionalization.

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Citations

May 31, 2019·Organic & Biomolecular Chemistry·Kaicheng LiJianmin Gao
Jun 4, 2019·Chemical Society Reviews·João P M AntónioPedro M P Gois
Sep 30, 2017·Chemical Communications : Chem Comm·Sean K LiewAndrei K Yudin
Oct 29, 2020·Chemical Society Reviews·Filip Van LijsebettenFilip E Du Prez
Aug 16, 2018·Accounts of Chemical Research·Samantha Cambray, Jianmin Gao

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