Abstract
African trypanosomiasis, otherwise known as sleeping sickness in humans and nagana in animals, is a parasitic protist passed cyclically by the tsetse fly. Despite more than a century of control and eradication efforts, the fly remains widely distributed across Africa and coextensive with other prevalent diseases. Control and planning are hampered by spatially and temporally variant vector distributions, ecologically irrelevant boundaries, and neglect. Tsetse are particularly well suited to move into previously disease-free areas under climate change scenarios, placing unprepared populations at risk. Here we present the modeling framework ATcast, which combines a dynamically downscaled regional climate model with a temporally and spatially dynamic species distribution model to predict tsetse populations over space and time. These modeled results are integrated with Kenyan population data to predict, for the period 2050 to 2059, exposure potential to tsetse and, by association, sleeping sickness and nagana across Kenya.
References
Jan 1, 1985·Annual Review of Entomology·D J Rogers, S E Randolph
Jan 9, 1999·Clinical Microbiology Reviews·G Hide
Sep 21, 2000·Bulletin of Entomological Research·J W Hargrove
Jan 4, 2001·Trends in Parasitology·B S Hursey
Jan 4, 2001·Trends in Parasitology·I F Grant
Jan 4, 2001·Trends in Parasitology·R Allsopp
Dec 17, 2002·Trends in Parasitology·David J Rogers, Sarah E Randolph
Jan 17, 2004·Clinical Microbiology Reviews·Robert W Sutherst
Sep 6, 2005·Trends in Parasitology·Stephen J TorrGlyn A Vale
Sep 25, 2007·Journal of Insect Physiology·John S TerblancheSteven L Chown
May 12, 2009·BMC Infectious Diseases·A Townsend Peterson
Aug 21, 2009·Parasitology·S C WelburnP P Simarro
Jan 26, 2010·PLoS Neglected Tropical Diseases·Camila GonzálezSahotra Sarkar
Mar 3, 2010·PloS One·Manisha A KulkarniJeremy T Kerr
Aug 3, 2010·PloS One·Nathan Moore, Joseph Messina
Aug 7, 2010·PLoS Medicine·Heather M FergusonGerry F Killeen
Nov 3, 2010·International Journal of Health Geographics·Pere P SimarroJean G Jannin
Citations
Aug 5, 2020·PloS One·April N FrakeJoseph P Messina
Mar 21, 2015·Vector Borne and Zoonotic Diseases·Emily Sohanna Acheson, Jeremy Thomas Kerr
Aug 15, 2018·The American Journal of Tropical Medicine and Hygiene·Winnie A OkeyoAdalgisa Caccone
Aug 8, 2020·Tropical Medicine and Health·Ferdinard AdungoMatilu Mwau
Jan 29, 2021·Transactions of the Royal Society of Tropical Medicine and Hygiene·Rachel TidmanRafael Ruiz de Castañeda
Jul 21, 2021·PloS One·Zewdu AbroKalinga Chilongo