Climate-specific biosynthetic gene clusters in populations of a lichen-forming fungus.

Environmental Microbiology
Garima SinghFrancesco Dal Grande

Abstract

Natural products can contribute to abiotic stress tolerance in plants and fungi. We hypothesize that biosynthetic gene clusters (BGCs), the genomic elements that underlie natural product biosynthesis, display structured differences along elevation gradients. We analysed biosynthetic gene variation in natural populations of the lichen-forming fungus Umbilicaria pustulata. We collected a total of 600 individuals from the Mediterranean and cold-temperate climates. Population genomic analyses indicate that U. pustulata contains three clusters that are highly differentiated between the Mediterranean and cold-temperate populations. One entire cluster is exclusively present in cold-temperate populations, and a second cluster is putatively dysfunctional in all cold-temperate populations. In the third cluster variation is fixed in all cold-temperate populations due to hitchhiking. In these two clusters the presence of consistent allele frequency differences among replicate populations/gradients suggests that selection rather than drift is driving the pattern. We advocate that the landscape of fungal biosynthetic genes is shaped by both positive and hitchhiking selection. We demonstrate, for the first time, the presence of climate-associ...Continue Reading

References

Jan 22, 2000·Die Naturwissenschaften·S Huneck
May 29, 2000·Trends in Genetics : TIG·P RiceA Bleasby
May 23, 2003·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Yngvar Gausla, Elin Margrete Ustvedt
Feb 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ilse KrannerHartwig W Pfeifhofer
Dec 3, 2005·Nature Reviews. Microbiology·Nancy P KellerJoan W Bennett
Jun 17, 2008·Journal of Natural Medicines·Hari Datta BhattaraiJoung Han Yim
Dec 17, 2008·PLoS Genetics·Sergey Kryazhimskiy, Joshua B Plotkin
May 18, 2010·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Katalin Molnár, Edit Farkas
Feb 1, 2011·Bioinformatics·Mitchell J SullivanScott A Beatson
Nov 2, 2011·Plant Signaling & Behavior·Akula Ramakrishna, Gokare Aswathanarayana Ravishankar
Sep 21, 2012·BMC Bioinformatics·Emanuele RaineriMiguel Pérez-Enciso
Oct 13, 2012·Frontiers in Plant Science·María L Falcone FerreyraPaula Casati
Oct 20, 2012·Fungal Genetics and Biology : FG & B·Gerald LacknerDirk Hoffmeister
Jun 29, 2013·Journal of Medicinal Chemistry·Kai SeehaferChristian D Klein
Dec 3, 2014·Fungal Genetics and Biology : FG & B·Daisuke HagiwaraSusumu Kawamoto
Dec 6, 2016·The New Phytologist·Garima SinghImke Schmitt
Nov 1, 1996·Oecologia·Knut A Solhaug, Yngvar Gauslaa
Jul 20, 2017·Proceedings of the National Academy of Sciences of the United States of America·Sean W BuskirkGregory I Lang
Sep 12, 2017·The New Phytologist·Francesco Dal GrandeImke Schmitt
Oct 11, 2017·Nature Microbiology·Nicholas J TobiasHelge B Bode
Nov 3, 2017·Chemical Society Reviews·Mark J CalcottJeremy G Owen
Dec 22, 2017·Methods in Ecology and Evolution·R Axel W WibergMichael G Ritchie
Jan 11, 2018·Proceedings of the National Academy of Sciences of the United States of America·Inge KjærbøllingMikael R Andersen
Mar 28, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li YangQiang Wang
Nov 1, 2018·Plant, Cell & Environment·David A Camarena-PozosLaila P Partida-Martínez
Jan 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anjuli CalcheraImke Schmitt

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