Climbing fibers in spinocerebellar ataxia: A mechanism for the loss of motor control

Neurobiology of Disease
C J L M Smeets, D S Verbeek

Abstract

The spinocerebellar ataxias (SCAs) form an ever-growing group of neurodegenerative disorders causing dysfunction of the cerebellum and loss of motor control in patients. Currently, 41 different genetic causes have been identified, with each mutation affecting a different gene. Interestingly, these diverse genetic causes all disrupt cerebellar function and produce similar symptoms in patients. In order to understand the disease better, and define possible therapeutic targets for multiple SCAs, the field has been searching for common ground among the SCAs. In this review, we discuss the physiology of climbing fibers and the possibility that climbing fiber dysfunction is a point of convergence for at least a subset of SCAs.

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Citations

Oct 13, 2018·Brain : a Journal of Neurology·Kai Yu Ma, Dineke S Verbeek
Apr 28, 2018·Journal of Neurology·Ming LiWei Yang
Aug 23, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Polina A Egorova, Ilya B Bezprozvanny
Jun 8, 2018·The Cerebellum·Polina A EgorovaIlya B Bezprozvanny
Apr 18, 2020·Frontiers in Neuroscience·Francesca BindaSmita Saxena
Sep 29, 2017·Frontiers in Neurology·Luis C Velázquez-PérezJuan Fernandez-Ruiz
Aug 9, 2020·Frontiers in Neuroscience·Katherine J RobinsonAngela S Laird
May 16, 2018·Frontiers in Synaptic Neuroscience·Eriola HoxhaFilippo Tempia
Jul 10, 2018·The Cerebellum·Martha L StrengTimothy J Ebner

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Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

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