PMID: 8937845Aug 1, 1996Paper

Clindamycin resistance among erythromycin-resistant Streptococcus pneumoniae

Diagnostic Microbiology and Infectious Disease
R N JonesA Wanger

Abstract

The increasing proportion of Streptococcus pneumoniae isolates with reduced susceptibility to penicillin has created an urgent need for therapeutic alternatives to some beta-lactam agents. Clindamycin is an antimicrobial agent with excellent bioavailability after oral administration which has been considered for the therapy of community-acquired pneumococcal otitis media. Using the Etest methodology, we have studied the in vitro susceptibility of 59 erythromycin-resistant strains of S. pneumoniae to clindamycin, penicillin, trimethoprim-sulfamethoxazole, and rifampin. The study also addressed the impact of the susceptibility test medium [Mueller-Hinton (MH) vs IsoSensitest (Iso), both 5% blood supplement] on the results. A total of 20 isolates (37%) displayed constitutive clindamycin resistance on Iso blood agar, compared with only 11 (22%) on MH blood agar. The remaining nine strains found to be clindamycin susceptible on MH manifested resistance only with erythromycin induction. Resistance to penicillin, rifampin, and trimethoprim-sulfamethoxazole in erythromycin-resistant isolates was 83%, 2%, and 85%-89% (medium dependent), respectively. These results indicate that the choice of susceptibility test medium affects the expres...Continue Reading

References

Aug 1, 1975·Antimicrobial Agents and Chemotherapy·P NicholasS Z Hirschman
Jan 1, 1964·Chemotherapy·J Desmyter, G Reybrouck
May 1, 1995·The Pediatric Infectious Disease Journal·G H McCracken
Apr 1, 1993·The Journal of Antimicrobial Chemotherapy·C DuckworthC H Wray

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Citations

May 5, 2001·Diagnostic Microbiology and Infectious Disease·M WangF Wang
Aug 26, 1999·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·A C FluitJ Verhoef
Oct 5, 2001·Clinical Microbiology Reviews·A C FluitF J Schmitz
Sep 17, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·G Perera, R Hay
Jul 6, 2004·The Laryngoscope·Karen LinArnold Komisar

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