Clindamycin/benzoyl peroxide gel (BenzaClin): a review of its use in the management of acne

American Journal of Clinical Dermatology
Kate McKeage, Gillian M Keating

Abstract

Clindamycin 1%/benzoyl peroxide 5% (BenzaClin) is a combination gel indicated for use twice daily, or as directed by a physician, for the topical treatment of inflammatory and noninflammatory lesions of acne vulgaris. In well designed clinical trials in patients with mild to moderately severe acne, the efficacy of once- or twice-daily clindamycin/benzoyl peroxide in the reduction of inflammatory lesion counts was greater than that of benzoyl peroxide alone, clindamycin alone, or tretinoin plus clindamycin, and not significantly different from that of erythromycin/benzoyl peroxide. In the reduction of noninflammatory lesion counts, the efficacy of once- or twice-daily clindamycin/benzoyl peroxide was greater than that of clindamycin alone, but not significantly different to that observed with benzoyl peroxide, tretinoin plus clindamycin, or erythromycin/benzoyl peroxide. Clindamycin/benzoyl peroxide has a fairly rapid onset of action, with acne improvement usually recorded within 2-4 weeks. Despite widespread use, bacterial resistance is not associated with clindamycin/benzoyl peroxide. The product is generally well tolerated, and the main treatment-related adverse events in clinical trials were application-site dryness, irritat...Continue Reading

References

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Citations

Nov 1, 2013·The Journal of Dermatological Treatment·William D HooverSteven R Feldman
May 27, 2011·Cutaneous and Ocular Toxicology·Hamidreza Pazoki-ToroudiAlireza Firooz
Aug 26, 2009·Experimental Dermatology·Catharina M LercheHans Christian Wulf
Feb 9, 2010·Risk Analysis : an Official Publication of the Society for Risk Analysis·Louis Anthony Tony Cox, Douglas A Popken
Feb 14, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·M T LecciaB Dreno

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