PMID: 2321069Apr 1, 1990

Clindamycin/primaquine therapy and secondary prophylaxis against Pneumocystis carinii pneumonia in patients with AIDS

Southern Medical Journal
R Kay, R E DuBois

Abstract

We found a program of intravenous and subsequent oral clindamycin, combined with oral primaquine, to be effective for Pneumocystis carinii pneumonia in nine patients with AIDS. The pneumonias were either primary or recurrent and sometimes severe, with cavity formation and/or pneumothorax. Maintenance therapy at lowered dose by mouth was effective in preventing recurrence in seven patients. One patient died of other opportunistic infections on day 24, and therapy was discontinued in another on day 11 because of skin rash. We conclude that clindamycin/primaquine is effective for therapy of P carinii pneumonia in patients with AIDS, as well as for long-term secondary prophylaxis at lowered dosage.

References

Nov 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·V KalanadhabhattaM Kramer
Jun 1, 1995·Journal of Clinical Pharmacy and Therapeutics·A E Jolley, J G Hastings
Jul 1, 1991·Antimicrobial Agents and Chemotherapy·M C Broughton, S F Queener
Nov 1, 1991·Chest·R McCabe
Mar 25, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Thomas BenfieldJannik Helweg-Larsen
Mar 1, 1991·Journal of Clinical Immunology·A CarrR Penny
Jun 13, 1998·Antimicrobial Agents and Chemotherapy·J A Fishman
May 21, 1998·Antimicrobial Agents and Chemotherapy·J A Fishman

Related Concepts

Clindamycin Oral Product
Recurrent Malignant Neoplasm
Polychemotherapy
Body Cavities
Dental Caries
Primacin
Dalacin C
Drug Evaluation
Recurrence (Disease Attribute)
Pneumocystis Jiroveci Pneumonia

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