Clinical activity is an independent risk factor of ischemic heart and cerebrovascular arterial disease in patients with inflammatory bowel disease

PloS One
Guillaume Le GallLaurent Beaugerie

Abstract

In inflammatory bowel disease (IBD), the impact of established cardiovascular risk factors and disease-related factors on the risk of acute arterial events is still unclear. We aimed to identify risk factors of acute arterial events in patients with IBD. All consecutive patients followed at Saint-Antoine Hospital between 1996 and 2015 with subsequent occurrence of acute arterial events (acute coronary syndrome or ischemic stroke) were identified. Traditional cardiovascular risk factors, treatment exposure, systemic inflammation (mean serum CRP level greater than or equal to 5 mg/L) and IBD clinical activity were assessed. A nested case-control study was performed including cases and controls without arterial ischemic event, matched on age, gender, and disease extent. A total of 30 patients (median age at acute vascular event occurrence: 42 years (interquartile range: 25-59)) developed acute coronary syndrome (n = 22) or ischemic stroke (n = 8). In univariate analysis, clinical disease activity and the persistence of systemic inflammation, diabetes, dyslipidemia and hypertension were significantly associated with an increased risk of acute arterial events. Neither protective nor aggravating effects associated with treatment expo...Continue Reading

References

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Citations

Jan 17, 2020·British Journal of Pharmacology·Antigone LazouIoanna Andreadou
Feb 23, 2020·Stroke; a Journal of Cerebral Circulation·Neal S ParikhCostantino Iadecola
Jan 11, 2020·European Journal of Gastroenterology & Hepatology·Aikaterini MantakaIoannis E Koutroubakis
Aug 14, 2020·Clinical and Experimental Medicine·Piotr CzubkowskiJarosław Kierkuś
Apr 4, 2021·Journal of the Neurological Sciences·José M Ferro, Miguel Oliveira Santos
Jun 23, 2021·Alimentary Pharmacology & Therapeutics·Charles N BernsteinRuth Ann Marrie
Aug 12, 2021·Therapeutic Advances in Gastroenterology·Jasmijn A M SleutjesAnnemarie C de Vries
Aug 29, 2021·Nature Reviews. Gastroenterology & Hepatology·Pablo A OliveraLaurent Peyrin-Biroulet

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