Clinical analysis of 82 cases of carcinoma showing thymus-like differentiation of the thyroid

Oncology Letters
Wei GeYi-Tao Ding

Abstract

The aim of the present study was to summarize the clinical characteristics, diagnosis, treatment and prognosis of carcinoma showing thymus-like differentiation of the thyroid (CASTLE). A search of the relevant literature was conducted, which identified 82 cases of CASTLE reported to date. A review of the clinical and auxiliary examination data, treatment, pathological findings and follow-up of these cases was performed. The clinical manifestations of CASTLE varied and did not demonstrate specificity. During ultrasound examination, CASTLE was described as a solid and hypoechoic mass, and the echo was typically observed to be heterogeneous. In computed tomography (CT), CASTLE was demonstrated to be a well-defined, soft tissue density mass without calcification, which appeared enhanced following administration of contrast medium. In emission CT, CASTLE was revealed as a 'cold nodule'. A total of 78 patients underwent radical surgery, and 12 patients experienced recurrence. Lymph node metastasis did not promote recurrence, and postoperative radiation was not able to reduce the recurrence rate (P=0.144 and 1.000, respectively). The median follow-up time was 14 months (range, 1-312 months). Typical immunohistochemical examinations de...Continue Reading

References

Feb 5, 2004·The British Journal of Surgery·S RokaC Armbruster
Jan 13, 2006·Thyroid : Official Journal of the American Thyroid Association·Noriko KusadaHiromitsu Yuasa
Oct 12, 2012·Journal of Clinical Ultrasound : JCU·Yayoi YamamotoAtsushi Kohno
Oct 31, 2012·Korean Journal of Pathology·Sunhee ChangHanseong Kim
Aug 8, 2013·Pathology, Research and Practice·Chuying HuangQiu Li

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Citations

Jul 17, 2020·International Journal of Surgical Pathology·Laura ArdighieriDavide Lombardi
Nov 9, 2017·Diagnostic Cytopathology·Madhu RajeshwariDeepali Jain
Sep 3, 2019·Frontiers in Oncology·Lisa LorenzAndreas Werner Jehle
Jun 24, 2021·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Petra KovářováJindřich Fínek
Nov 23, 2021·Head and Neck Pathology·Michał KuncWojciech Biernat

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