Abstract
To analyze the clinical characteristics and chemo-resistance related factors of patients with resistant and non-resistant endometriosis-associated ovarian cancer (ovarian clear cell carcinoma and endometrioid carcinoma) by reviewing the data of epithelial ovarian cancer patients who received initial treatment in our hospital over a 12-year period. Among the 304 patients, 17.1% were seen with platinum-based drug resistance. The ROC curve of continuous variables was drawn according to resistance situation, then they were grouped by age (< 48 or ≥ 48 years), tumor size (< 7 cm or ≥ 7 cm) and Ca125 (< 90 and ≥ 90 U/ml). In univariate analysis, age ≥ 48 years, initial symptom of abdominal distension or weight loss, abnormal preoperative serum Ca125, Ca125 < 90 U/ml, advanced FIGO stage, absence of endometriosis, bilateral tumors, lack of lymphadenectomy, positive lymph nodes, unsatisfactory initial cytoreduction surgery and history of breast cancer were all related to drug resistance in ovarian cancer. In multivariate analysis, advanced stage, lack of lymphadenectomy, positive lymph nodes and history of breast cancer were independent risk factors related to platinum-based drug resistance (P < 0.05). For patients of endometriosis-rel...Continue Reading
References
Sep 19, 1998·Gynecologic Oncology·K BehbakhtS C Rubin
Jan 12, 1999·Experimental Cell Research·N Claij, H te Riele
Apr 15, 1999·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·C D RolitskyT H Niemann
Feb 8, 2002·Cell·Ricky W JohnstoneScott W Lowe
Jul 26, 2002·Oncology·Hiroaki ItamochiNaoki Terakawa
May 13, 2004·Human Pathology·Kathy Qi CaiJinsong Liu
Apr 2, 2008·Cancer Science·Hiroaki ItamochiNaoki Terakawa
Apr 9, 2008·Gynecologic Oncology·John K ChanDaniel S Kapp
Jul 29, 2010·Molecular Cancer Therapeutics·Seiji MabuchiTadashi Kimura
Aug 5, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Helen J MackayUNKNOWN Gynecologic Cancer InterGroup
Jan 12, 2011·Angiogenesis·G K SiddiquiG M Boxer
Mar 1, 2012·Gynecologic Oncology·J Alejandro Rauh-HainMarcela G Del Carmen
Jan 25, 2013·Journal of Gynecologic Oncology·Morikazu MiyamotoKenichi Furuya
Dec 24, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Hiroaki ItamochiTasuku Harada
Mar 7, 2014·Cancer Science·Kaoru NiimiMasahide Takahashi
Jul 3, 2015·BMC Cancer·Marjo Pylväs-EerolaUlla Puistola
Apr 9, 2017·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Fei-Chun KuChyong-Huey Lai
Citations
May 4, 2020·Journal of Ovarian Research·Natsuho NakamuraMasahide Ohmichi
May 25, 2021·Journal of Chemotherapy·Feiyue ZengYingzi Liu
Jun 21, 2021·Journal of Ethnopharmacology·Xiao XuWeiling Li
Aug 26, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Anna GreerMichael Worley