Clinical analysis of childhood pancreatoblastoma arising from the tail of the pancreas

Journal of Pediatric Hematology/oncology
Chang XuChunyan Wang

Abstract

Pancreatoblastoma is a rare pancreatic tumor. In this study, 3 cases of childhood pancreatoblastoma that arise from the tail of the pancreas were reported. Abdominal pain and vomiting were observed in 1 case considering the huge size of the tumor. The other 2 patients, who were previously well, complained of a mass in the abdomen after a casual physical examination. Elevated serum α-fetoprotein levels were noted in all cases. Imaging findings indicated a well-defined heterogeneous large mass in the left retroperitoneal space. Exploratory laparotomy revealed a large mass, arising from the tail of the pancreas. Surgery alone with complete excision of the masses was performed. Immunohistochemical staining showed that only α-fetoprotein was positive in all cases. All of these 3 cases have a good outcome in the follow-up without adjuvant chemotherapy. These data suggest that the diagnosis of pancreatoblastoma is difficult and should be suspected at palpation of an abdominal mass. α-Fetoprotein may serve as a tumor marker for preoperative diagnosis and postoperative recurrence. Pancreatoblastoma arising from the tail of the pancreas is a curable tumor, and adjuvant chemotherapy may not be necessary if the tumor can be excised complet...Continue Reading

References

Dec 1, 1992·Journal of Pediatric Surgery·Y InomataK Tanaka
Oct 1, 1990·Journal of Pediatric Surgery·J L GrosfeldK W West
Dec 1, 1988·Archives of Disease in Childhood·S J PassmoreA Oakhill
Nov 1, 1996·Journal of Clinical Pathology·C HuaC Lei
Dec 13, 1997·Journal of Pediatric Surgery·Y ChunS Jung
Jul 23, 1998·World Journal of Surgery·S VossenU Willnow
Aug 11, 2000·Acta Radiologica·E KohdaM Saeki
Nov 18, 2000·Journal of Pediatric Surgery·B OgawaT Imamura
Mar 13, 2001·Digestive Surgery·K P RiesenerV Schumpelick
May 31, 2002·Journal of Pediatric Surgery·Nicholas A ShorterMichael P Laquaglia
Oct 22, 2003·Archives of Pathology & Laboratory Medicine·Emma DuAhmed Shabaik
Jul 17, 2004·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·A R DhebriJ P Neoptolemos
Apr 21, 2005·Pancreas·Kyoko MiyasakaAkihiro Funakoshi
Jun 14, 2006·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Supriya RajpalEmily K Bergsland
Jul 18, 2006·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Ellen M ChungRichard M Conran
Nov 3, 2006·Pancreas·Edward L Bradley
Jan 2, 2007·Pancreas·Liping Cao, Daren Liu
Dec 20, 2007·Journal of Pediatric Hematology/oncology·Yong Jik Lee, Jeong Ok Hah
Mar 1, 2008·Cancer Letters·Wei Zhong GuHong Feng Tang
Dec 17, 2008·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Alvise CavalliniGiovanni Butturini

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