Abstract
Fever of unknown origin (FUO) was first described in 1961 as fever >38.3°C for at least 3 weeks with no apparent source after 1 week of investigations in the hospital. Infectious disease comprises the majority of cases (40-60%). There is no related research on FUO in children in Taiwan. The aim of this study is to determine the etiologies of FUO in children in Taiwan and to evaluate the relationship between the diagnosis and patient's demography and laboratory data. Children under 18 years old with fever >38.3°C for >2 weeks without apparent source after preliminary investigations at Taipei Veterans General Hospital during 2002-2012 were included. Fever duration, symptoms and signs, laboratory examinations, and final diagnosis were recorded. The distribution of etiologies and age, fever duration, laboratory examinations, and associated symptoms and signs were analyzed. A total of 126 children were enrolled; 60 were girls and 66 were boys. The mean age was 6.7 years old. Infection accounted for 27.0% of cases, followed by undiagnosed cases (23.8%), miscellaneous etiologies (19.8%), malignancies (16.6%), and autoimmune disorders (12.7%). Epstein-Barr virus (EBV) and cytomegalovirus (CMV) were the most commonly found pathogens for...Continue Reading
References
Aug 1, 1976·Current Problems in Pediatrics·R D Feigin, W T Shearer
Oct 1, 1991·The Journal of Pediatrics·R W SteeleC M Glasier
Jul 1, 1990·Infection·A E MouaketN al-Quod
Oct 1, 1984·Journal of Computer Assisted Tomography·D PicusD M Balfe
Jan 1, 1993·Pediatric Radiology·C Buonomo, S T Treves
Sep 1, 1996·The Journal of Pediatrics·L C MillerJ G Schaller
Nov 20, 1997·Lancet·E GalanakisP D Lapatsanis
Feb 10, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R F Jacobs, G E Schutze
Jan 13, 2001·Clinical Pediatrics·J A Talano, B Z Katz
May 17, 2001·Paediatric Drugs·G O Akpede, G I Akenzua
Jan 23, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Debra L PalazziSheldon L Kaplan
Feb 1, 1961·Medicine·R G PETERSDORF, P B BEESON
Oct 3, 2003·Pediatrics International : Official Journal of the Japan Pediatric Society·Ozgur CoguluCihangir Ozkinay
May 25, 2006·Acta Paediatrica·Srdjan PasicMilanka Markovic
Dec 16, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Chantal P Bleeker-RoversWim J G Oyen
Jan 16, 2007·Medicine·Chantal P Bleeker-RoversJos W M van der Meer
Aug 22, 2007·Blood·Pamela SeamBruce D Cheson
Feb 19, 2010·Clinical Pediatrics·Robert W Tolan
Jan 8, 2011·Pediatric Annals·Carl J Seashore, Jacob A Lohr
Apr 15, 2011·International Journal of Molecular Imaging·Nurhan Ergül, Tevfik Fikret Cermik
Feb 7, 2012·Journal of Epidemiology·Ritei Uehara, Ermias D Belay
May 22, 2013·American Journal of Clinical Pathology·Flavia G N Rosado, Annette S Kim
Citations
May 5, 2016·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Ya-Li ChienPo-Yen Chen
May 18, 2018·Human Molecular Genetics·Tai-Ming KoYusuke Nakamura
Mar 2, 2018·PloS One·Jingtao CuiAnping Ni
Aug 1, 2019·The Clinical Respiratory Journal·Ying JiangYubao Guan
Sep 14, 2019·Medicine·Keh-Sen LiuChun-Yi Lin
Dec 29, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Teng XuHaihui Huang