Clinical analysis of hyponatremia in acute craniocerebral injury

The Journal of Emergency Medicine
Wenchuan ZhangJiyao Jiang

Abstract

To explore pathological mechanisms of central hyponatremia and its treatment. Synchronous assay was made for changes of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), endogenous digitalis-like substance (EDLS), antidiuretic hormone (ADH) in blood, and Na(+) concentrations in blood and urine, and plasma- and urine-osmolality in 68 patients with acute craniocerebral injury (ACI). Of the 68 patients with ACI, 27 were found to have hyponatremia, and such illness was mostly concentrated on severe cases. The central hyponatremia in patients with ACI may be related to the increase in the secretion of EDLS and ADH as the result of damaged functions of the hypothalamic-hypophysial system, and it seems that the decrease in blood ANP and BNP has no direct effect on Na(+) concentrations in blood. Inappropriate secretion of antidiuretic hormone syndrome and cerebral salt-wasting syndrome are the two main reasons for hyponatremia in patients with craniocerebral injury. The pathological mechanism, diagnostic standards, as well as treatment methods for the two, however, are not just the same. Intravenous injection of extrinsic thyrotropin-releasing hormone might inhibit dilutional hyponatremia arising from the increase in A...Continue Reading

References

Mar 10, 2001·The Journal of Trauma·J A DoyleD B Hoyt
Mar 14, 2001·The Netherlands Journal of Medicine·M J CoenraadJ H Bolk
Aug 23, 2001·Archives of Disease in Childhood·A AlbaneseR Stanhope
Apr 26, 2003·Trends in Endocrinology and Metabolism : TEM·Biff F Palmer
Nov 25, 2003·The Neurologist·Alejandro A Rabinstein, Eelco F M Wijdicks
Jun 12, 2004·Neurosurgical Focus·Chad D ColeWilliam T Couldwell
Apr 2, 2005·Stroke; a Journal of Cerebral Circulation·A M MäkikallioV V Myllylä

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Citations

Nov 13, 2015·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Jan LeonardDavid Bar-Or
Oct 15, 2020·The Journal of International Medical Research·Xianliang ZhongBo Du

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