Clinical and analytical toxicology of dietary supplements: a case study and a review of the literature

Biological Trace Element Research
Gijsbert B van der VoetFlorabel G Mullick

Abstract

The use of dietary supplements has grown dramatically in the last decade. A large number of dietary and herbal supplements escape regulatory and quality control; components of these preparations are poisonous and may contain, among other toxins, heavy metals. Uncontrolled use of dietary and herbal supplements by special populations, such as the military, may therefore pose a health risk. Clinical symptoms are not always properly attributed to dietary supplements; patients often do not mention supplement use to their health care provider. Therefore, a health risk estimate is hard to make on either the individual or the population level. The literature on this issue was reviewed and discussed in the light of a representative clinical-chemical case study. This case study was performed on a host of preparations that were used by one single individual in the military. Both essential (chromium, copper, zinc, and iron) and poisonous (arsenic, lead, and nickel) trace elements were determined using inductively coupled plasma combined with optical emission spectrometry (ICP-OES) or with mass spectrometry (ICP-MS). Arsenic and lead were detected at exposure levels associated with health risks. These health risks were detected predominantl...Continue Reading

References

Jan 16, 2002·JAMA : the Journal of the American Medical Association·David W KaufmanAllen A Mitchell
Mar 7, 2002·Trends in Pharmacological Sciences·Edzard Ernst
Feb 16, 2005·Archives of Internal Medicine·Judith P KellyAllen A Mitchell
May 27, 2005·Drugs·Zeping HuShufeng Zhou
Jan 24, 2006·Life Sciences·Mary L ChavezPedro I Chavez
Aug 15, 2006·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Christine A Haller
Aug 15, 2006·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Richard Ko
Nov 28, 2006·Journal of the American Dietetic Association·Babgaleh B TimboChung-Tung J Lin
Feb 12, 2008·The American Journal of Medicine·Bimal H Ashar, Anastasia Rowland-Seymour
Mar 11, 2008·The American Journal of Medicine·Amit SoodDietlind L Wahner-Roedler
Mar 20, 2008·Current Medical Research and Opinion·Richard SadovskyRichard Safeer

❮ Previous
Next ❯

Citations

Dec 1, 2012·Environmental Monitoring and Assessment·Leticia García-Rico, Lourdes Tejeda-Valenzuela
Jul 19, 2011·Metallomics : Integrated Biometal Science·Erika MitchellBibudhendra Sarkar
Oct 5, 2010·Journal of the American Academy of Dermatology·Dirk M Elston
Feb 23, 2011·Phytochemical Analysis : PCA·Xudong YuanZhiqian Wu
Mar 13, 2014·Medical Hypotheses·John F Kalinich, Christine E Kasper
Nov 23, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A PetrocziD P Naughton
Mar 8, 2016·International Journal of Molecular Sciences·Mark I AviganLeonard B Seeff
Apr 16, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Cindy CrawfordPatricia Deuster

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.