Clinical and Basic Research Progress on Treg-Induced Immune Tolerance in Liver Transplantation.

Frontiers in Immunology
Xuhao NiLing Lu

Abstract

Rejection after organ transplantation is a cause of graft failure. Effectively reducing rejection and inducing tolerance is a challenge in the field of transplantation immunology. The liver, as an immunologically privileged organ, has high rates of spontaneous and operational tolerance after transplantation, allowing it to maintain its normal function for long periods. Although modern immunosuppression regimens have serious toxicity and side effects, it is very risky to discontinue immunosuppression regimens blindly. A more effective treatment to induce immune tolerance is the most sought-after goal in transplant medicine. Tregs have been shown to play a pivotal role in the regulation of immune balance, and infusion of Tregs can also effectively prevent rejection and cure autoimmune diseases without significant side effects. Given the immune characteristics of the liver, the correct use of Tregs can more effectively induce the occurrence of operational tolerance for liver transplants than for other organ transplants. This review mainly summarizes the latest research advances regarding the characteristics of the hepatic immune microenvironment, operational tolerance, Treg generation in vitro, and the application of Tregs in live...Continue Reading

References

Jan 27, 1997·Transplantation·G V MazariegosT E Starzl
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P A KnolleG Gerken
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J DevlinR Williams
Jan 11, 2003·Science·Shohei HoriShimon Sakaguchi
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Venu G PillarisettyRonald P DeMatteo
Dec 14, 2004·Immunity·Mattias SvenssonPaul M Kaye
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·An De CreusAngus W Thomson
Feb 15, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Panagiotis TryphonopoulosCamillo Ricordi
May 10, 2005·Transplantation·James D EasonGeorge E Loss
May 28, 2005·Transplantation Proceedings·R GirlandaN D Heaton
Jun 18, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christiane WiegardAnsgar W Lohse
Oct 26, 2005·Nature Immunology·Karsten KretschmerHarald von Boehmer
Feb 1, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ahmet DemirkiranLuc J W van der Laan
Dec 19, 2006·Transplantation Proceedings·W LiJ D Perkins
Jan 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T Peter KinghamRonald P DeMatteo
Mar 23, 2007·Nature·Masahiro OnoShimon Sakaguchi
Mar 19, 2008·Immunology·Dorothy K SojkaDeborah J Fowell
Jun 21, 2008·Nature Reviews. Immunology·Dario A A VignaliCreg J Workman
Jul 23, 2008·Journal of Hepatology·Davide Mineo, Camillo Ricordi
Aug 21, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Qiang YouCynthia Ju
Sep 20, 2008·Nature Reviews. Immunology·Alfred SingerJung-Hyun Park
Mar 24, 2009·Annual Review of Immunology·Ian Nicholas Crispe
Jul 4, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ekaterina BreousJames M Wilson
Jul 30, 2009·Seminars in Immunopathology·Eszter NemethCliona O'Farrelly
Sep 30, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nils KruseKatja Klugewitz
Feb 5, 2010·Journal of Transplantation·Sandeep Mukherjee, Urmila Mukherjee
Mar 10, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anna SchurichPercy A Knolle
Mar 23, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ling LuSong Guo Zheng
Feb 3, 2011·Methods in Molecular Biology·Shimon Sakaguchi
Aug 19, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Alberto Sánchez-Fueyo
Nov 15, 2011·Gastroenterology·Nobuhiro NakamotoToshifumi Hibi
Apr 18, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Benjamin M MattaAngus W Thomson
May 9, 2012·Frontiers in Immunology·Angelika SchmidtPeter H Krammer
Jul 17, 2012·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Mauro Di IanniFranca Falzetti
Nov 1, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhigang TianBin Gao

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