Clinical and Biochemical Evaluation of Lozenges Containing Lactobacillus reuteri as an Adjunct to Non-Surgical Periodontal Therapy in Chronic Periodontitis

Journal of Periodontology
Gizem İnceSelçuk Yılmaz

Abstract

This study evaluates the effects on clinical and biochemical parameters of Lactobacillus reuteri-containing probiotic supplementation adjunctive to initial periodontal therapy in patients with chronic periodontitis (CP). Thirty patients with CP were included and divided into two groups. Every patient had, in each quadrant, ≥2 teeth each with approximal sites with a probing depth (PD) of 5 to 7 mm and gingival index (GI) of ≥2. The test group received scaling and root planing (SRP) and probiotic-containing lozenges. The control group received SRP and placebo lozenges. Plaque index (PI), GI, bleeding on probing (BOP), PD, and attachment gain were measured. Gingival crevicular fluid (GCF) was sampled for the analysis of matrix metalloproteinase (MMP)-8 and tissue inhibitor of metalloproteinase (TIMP)-1 by enzyme-linked immunosorbent assay. All evaluations were performed at baseline and on days 21, 90, 180, and 360. Differences in intergroup comparisons of PI, GI, BOP, and PD were found to be significant (P <0.05) in favor of the test group at all time points. Decreased GCF MMP-8 levels and increased TIMP-1 levels were found to be significant up to day 180 (P <0.05). Mean values of attachment gain were significantly higher in the t...Continue Reading

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Citations

Oct 2, 2015·Journal of Clinical Periodontology·Isabelle LalemanWim Teughels
Sep 24, 2016·Journal of Periodontology·Luiz F F OliveiraMichel R Messora
Aug 2, 2017·Periodontology 2000·Filippo GrazianiDavid Herrera
Dec 5, 2017·Current Oral Health Reports·Robert P Allaker, Abish S Stephen
Aug 5, 2018·Journal of Clinical Periodontology·Marcos M InverniciMichel R Messora
Nov 11, 2019·Clinical Oral Implants Research·Isabelle LalemanWim Teughels
Feb 26, 2020·Current Opinion in Neurology·Mahtab SadrameliLavinia Alberi
Jun 9, 2020·Journal of Clinical Periodontology·Georgios PelekosColman McGrath
Oct 3, 2020·Drug Development and Industrial Pharmacy·Anja HoffmannRolf Daniels
Aug 30, 2019·Scientific Reports·Sanjay Kumar TiwariLei Cheng
Aug 28, 2020·Periodontology 2000·Srinivas Rao MyneniHoward H Wang
May 26, 2016·Expert Review of Anti-infective Therapy·Victor Haruo MatsubaraLakshman Perera Samaranayake
Mar 6, 2021·PloS One·Paul Mathias JansenGeorg Conrads
Mar 11, 2021·Periodontology 2000·Jessica D Hathaway-Schrader, Chad M Novince
Mar 25, 2021·Expert Opinion on Drug Delivery·Anže ZidarŠpela Zupančič
May 10, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lorena Vasconcelos VieiraDelane Viana Gondim

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