Clinical and biochemical evidence of control of prostate cancer at 5 years after external beam radiation

The Journal of Urology
G E HanksT E Schultheiss

Abstract

We demonstrate the 5-year survival rate for patients with prostate cancer treated by irradiation, the value of the conformal technique and prostate specific antigen (PSA) doubling times after irradiation. The outcome of 502 consecutive patients with stages T1 to T3 prostate cancer treated by irradiation alone is reported. PSA doubling times before and after failure are reported for 13 patients and posttreatment PSA doubling times are reported for 93 consecutive patients in whom radiation failed. The actuarial survival with biochemical freedom from disease (PSA nadir 1.5 or less not increasing) at 5 years was 44% for all patients, 50% for the conformal treatment group and 39% for the conventional therapy group. PSA doubling times after radiation failure were variable, with 42% greater than 12 months. The 5-year survival rate for patients with prostate cancer treated by irradiation is excellent. The conformal technique is superior to conventional therapy and there is no evidence that irradiation accelerates the growth rate of prostate cancer.

References

Sep 1, 1990·International Journal of Radiation Oncology, Biology, Physics·P P LaiM A Lockett
Jul 1, 1985·International Journal of Radiation Oncology, Biology, Physics·G E Hanks
May 15, 1995·International Journal of Radiation Oncology, Biology, Physics·B W CornL R Coia
Sep 30, 1994·International Journal of Radiation Oncology, Biology, Physics·G E HanksT F Pajak
Jan 1, 1994·International Journal of Radiation Oncology, Biology, Physics·G E HanksJ B Owen

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Citations

Jan 1, 1997·World Journal of Urology·G E HanksT E Schultheiss
Jul 8, 1999·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·C J Rossi
Feb 1, 1996·International Journal of Radiation Oncology, Biology, Physics·G E HanksT E Schultheiss
Jan 1, 1996·Urologic Oncology·C N Coleman, M A Stevenson
Nov 11, 2003·Critical Reviews in Oncology/hematology·Sergio VillaPatrizia Olmi
Mar 9, 2005·International Journal of Radiation Oncology, Biology, Physics·Steven J FeigenbergAlan Pollack
Jul 1, 1997·Urology·G E HanksB Movsas
May 1, 1999·Urology·J D SlaterJ M Slater
Sep 21, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Michael BrundageUNKNOWN Cancer Care Ontario Practice Guidelines Initiative Genitourinary Cancer Disease Site Group
Feb 1, 1997·International Journal of Radiation Oncology, Biology, Physics·G E HanksL R Coia
May 1, 1997·International Journal of Radiation Oncology, Biology, Physics·K KagawaG E Hanks
Jun 1, 1997·International Journal of Radiation Oncology, Biology, Physics·J P LattanziG E Hanks
Dec 10, 1997·International Journal of Radiation Oncology, Biology, Physics·P R AndersonG E Hanks
Nov 22, 1997·International Journal of Radiation Oncology, Biology, Physics·C A PerezT H Wasserman
Dec 10, 1997·International Journal of Radiation Oncology, Biology, Physics·T GranforsA Widmark
Oct 27, 1998·International Journal of Radiation Oncology, Biology, Physics·J D SlaterJ M Slater
Mar 17, 1999·International Journal of Radiation Oncology, Biology, Physics·A V D'AmicoJ P Richie
May 30, 1998·Journal of the National Cancer Institute·M W KattanP T Scardino
Nov 1, 1996·The Urologic Clinics of North America·E T Goluboff, M C Benson

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