PMID: 9447296Aug 1, 1997Paper

Clinical and biochemical presentation of primary hyperparathyroidism in Kansai district of Japan

Endocrine Journal
T KobayashiK Chihara

Abstract

Although the number of patients with primary hyperparathyroidism (pHPT) has increased since biochemical screening came to be widely employed, few data are available concerning the clinical analysis of Japanese patients. We therefore tried to determine the recent clinical and biochemical state of Japanese patients with pHPT. Clinical and biochemical data were analyzed in a series of 103 pHPT patients who had been hospitalized in Kobe University Hospital during a 17 year period from 1979 to 1995. The data were obtained from the hospital records and additionally from information through questionnaires performed in 1995. Patients were 29 males and 74 females. The average ages at diagnosis were 53.4 +/- 16.0 (SD) year-old and 53.9 +/- 15.2 year-old, respectively. The major clinical symptoms were nephrolithiasis (35.9%), thirst/polyuria (33.0%), easy fatigability (20.4%) and back pain/lumbago (16.5%), but 19.4% of the patients were asymptomatic. Out of 87 cases who received parathyroidectomy, 10 (11.5%) were diagnosed with parathyroid carcinoma. Age- and sex-corrected bone mineral density (BMD) of the radius was significantly lower in the group with back pain/lumbago than in the group without the symptom. Similarly, radial BMD was lo...Continue Reading

Citations

Jul 29, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·T YamaguchiK Chihara
Sep 1, 1999·Clinical Endocrinology·M KanzawaK Chihara
May 20, 2016·Nature Reviews. Disease Primers·John P BilezikianFrancisco Bandeira
Jun 8, 2000·The Journal of Clinical Endocrinology and Metabolism·D NakaokaK Chihara
Sep 8, 2020·Journal of Bone and Mineral Metabolism·Ashutosh Kumar AryaSudhaker D Rao

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