Abstract
The Philadelphia (Ph) chromosome was the first chromosomal abnormality associated with a specific leukemia, chronic myeloid leukemia (CML). This chromosome arises from the t(9;22)(q34;q11) translocation which results in the juxtaposition of the bcr gene and the abl proto-oncogene. This BCR/ABL fusion gene encodes for a hybrid protein with the capacity of oncogenic transformation of hematopoietic cells. Nonetheless, very few myeloproliferative disorders (about 10%) included under the generic term of CML have no Ph chromosome. Half of these Ph-negative CML have the BCR/ABL fusion gene (BCR-positive) and are considered equivalent to Ph-positive CML. In contrast, the patients without detectable BCR/ABL fusion (BCR-negative) fulfil the criteria for atypical CML (aCML) of the French-American-British (FAB) classification, despite considerable variability at the individual level. Due to the very small number of patients with precise cytological descriptions already published, cooperative studies focused on aCML are warranted to draw definitive conclusions and to provide some pointers on physiopathology.
References
Jan 1, 1992·British Journal of Haematology·M H FreedmanZ Estrov
Aug 1, 1992·Leukemia & Lymphoma·D A Galton
Aug 1, 1991·Cancer Genetics and Cytogenetics
Apr 1, 1991·Cancer Genetics and Cytogenetics·D C van der PlasA Hagemeijer
Dec 1, 1985·The Journal of Experimental Medicine·C R Bartram
Jul 1, 1988·Cancer Genetics and Cytogenetics·J H OhyashikiK Toyama
Jun 20, 1987·Lancet·O DreazenR P Gale
Mar 20, 1986·Nature·C M MorrisD C Heaton
Mar 1, 1986·Cancer Genetics and Cytogenetics
Feb 1, 1986·American Journal of Clinical Pathology·L B TravisG W DeWald
Mar 15, 1986·Cancer Genetics and Cytogenetics·C R Bartram, F Carbonell
Nov 1, 1986·Cancer·H M KantarjianE J Freireich
Jul 1, 1987·British Journal of Haematology·P H FitzgeraldA E Reeve
Jul 1, 1985·British Journal of Haematology·W C PughJ D Rowley
Feb 1, 1970·Annals of Internal Medicine·E Z EzdinliA A Sandberg
Jun 1, 1995·British Journal of Haematology·R CostelloD Maraninchi
Aug 1, 1994·British Journal of Haematology·J M BennettC Cox
Apr 22, 1994·Cell·C L Sawyers, C T Denny
Apr 22, 1994·Cell·T R GolubD G Gilliland
Oct 15, 1993·Cancer Genetics and Cytogenetics·Z ChenA A Sandberg
Jan 1, 1993·Leukemia & Lymphoma·R HehlmannC Falge
Jan 1, 1993·Cancer Genetics and Cytogenetics·A AmielM Lishner
Feb 1, 1993·Cancer Genetics and Cytogenetics·D C SeongJ M Trujillo
Mar 1, 1996·British Journal of Haematology·D G Oscier
Citations
Aug 12, 2009·Journal of Hematopathology·Daniel NeureiterOtto Dietze
Jan 1, 2009·BMJ Case Reports·Ashraf ElbahrawyRamadan Ragab
Oct 8, 1999·Leukemia & Lymphoma·T RobakM Debiec-Rychter
Aug 23, 2000·Leukemia & Lymphoma·D BenedekD Söhngen
Feb 1, 2012·Seminars in Oncology·Hideki MuramatsuJaroslaw P Maciejewski
Oct 17, 2003·Hematology/oncology Clinics of North America·Adewale Adeyinka, Gordon W Dewald
Sep 1, 2001·British Journal of Haematology·W Y AuY L Kwong
Oct 5, 2002·Cancer·Francesco OnidaMiloslav Beran
Oct 17, 2003·Hematology/oncology Clinics of North America·Tracy I George, Daniel A Arber
Aug 15, 2003·Leukemia & Lymphoma·W Y AuY L Kwong
Dec 12, 2017·Future Oncology·Prajwal DhakalVijaya Raj Bhatt
Nov 2, 2004·Bone Marrow Transplantation·M KoldehoffA H Elmaagacli
Feb 3, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sonya B ShahCarol L Shields
Jun 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R KurzrockM Talpaz