Clinical and biological correlations in celiac disease in children: the prospective single experience of a romanian tertiary center: A case-control study (Strobe-Compliant study)

Medicine
Cristina Oana MargineanMinodora Dobreanu

Abstract

Celiac disease-a chronic inflammatory disease of the intestine-is triggered by gluten or associated protein consumption.The aim of our study was to assess the sensitivity, specificity of the combined anti-transglutaminase 2 (TG2)/deamidated gliadin peptide antibodies (DGP), and antiendomisium antibodies (EMA), to determine the distribution of HLA-DQ2/DQ8 for the 140 tested patients, and also to evaluate the clinical and laboratory characteristics of patients admitted with the suspicion of celiac disease (CD). Children included in the study were divided into: group 1, patients with confirmed CD; group 2, patients with "potential' CD; group 3, control group, patients without CD. We assessed the standard laboratory data, the level of TG2/DGP and EMA antibodies, as well as the distribution of HLA molecules in the selected patients. Histopathological examination was considered the criterion standard for diagnosis in most cases.The sensitivity of TG2/DGP was 85% and the specificity 92%. EMA showed a sensitivity of 82% and a specificity of 98%. The vast majority of patients diagnosed with CD were either HLA-DQ2.5 (encoded by DQA1*05 & DQB1*02) positive (87.5%) or HLA-DQ8 (encoded by DQB1*03:02) positive (12.5%). One patient showed a p...Continue Reading

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Citations

Jun 1, 2018·Medicine·Cristina Oana MărgineanMaria Oana Mărginean
Sep 22, 2018·Medicine·Cristina Oana MărgineanCristian Dan Mărginean
Jan 18, 2020·Current Pediatric Reviews·Atifete Ramosaj-MorinaRenata Zunec

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Methods Mentioned

BETA
biopsies
deamidation
biopsy
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

Excel
GraphPad Instat

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