Clinical and biological impact of the exposome on the skin

Journal of the European Academy of Dermatology and Venereology : JEADV
Thierry PasseronChristos C Zouboulis

Abstract

The skin exposome is defined as the totality of environmental exposures over the life course that can induce or modify various skin conditions. Here, we review the impact on the skin of solar exposure, air pollution, hormones, nutrition and psychological factors. Photoageing, photocarcinogenesis and pigmentary changes are well-established consequences of chronic exposure of the skin to solar radiation. Exposure to traffic-related air pollution contributes to skin ageing. Particulate matter and nitrogen dioxide cause skin pigmentation/lentigines, while ozone causes wrinkles and has an impact on atopic eczema. Human skin is a major target of hormones, and they exhibit a wide range of biological activities on the skin. Hormones decline with advancing age influencing skin ageing. Nutrition has an impact on numerous biochemical processes, including oxidation, inflammation and glycation, which may result in clinical effects, including modification of the course of skin ageing and photoageing. Stress and lack of sleep are known to contribute to a pro-inflammatory state, which, in turn, affects the integrity of extracellular matrix proteins, in particular collagen. Hormone dysregulation, malnutrition and stress may contribute to inflam...Continue Reading

References

Jul 5, 1990·The New England Journal of Medicine·D RudmanD E Mattson
Feb 15, 1997·The Journal of Clinical Investigation·C Roméro-GrailletR Ballotti
May 12, 2001·The Journal of Investigative Dermatology·M FritschC C Zouboulis
Feb 15, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·F PoliM Verschoore
Feb 28, 2002·Annual Review of Immunology·Jeanette I WebsterEsther M Sternberg
May 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Christos C ZouboulisStefan R Bornstein
Jul 13, 2002·Annals of the New York Academy of Sciences·Farideh Eskandari, Esther M Sternberg
Sep 14, 2002·The Journal of Dermatology·Kabir SardanaRashmi Sarkar
Nov 20, 2002·Archives of Dermatology·Gary J FisherJohn J Voorhees
Oct 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pierre Saint-MezardFrédéric Bérard
Dec 24, 2003·Acta Dermato-venereologica·Choon Shik YounJin Ho Chung
May 1, 2004·Dermatology : International Journal for Clinical and Investigative Dermatology·Albert M Kligman
Oct 4, 2005·Journal of the American Academy of Dermatology·Glenda Hall, Tania J Phillips
Sep 20, 2006·Hormones : International Journal of Endocrinology and Metabolism·Christos C Zouboulis
Oct 13, 2006·Dermatology : International Journal for Clinical and Investigative Dermatology·WenChieh ChenChristos C Zouboulis
Jan 26, 2007·Pigment Cell Research·Yoshinori MiyamuraVincent J Hearing
Feb 28, 2007·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·C C ZouboulisR Rosenfield
Apr 27, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hiroo AmanoOsamu Ishikawa
Jul 27, 2007·Climacteric : the Journal of the International Menopause Society·P-G SatorH Hönigsmann
Aug 22, 2007·The Journal of Nutrition·Serge HercbergDenis Malvy
Feb 5, 2008·Maturitas·Stéphanie NouveauOlivier de Lacharriere
May 14, 2008·Experimental Dermatology·Christos C ZouboulisAnja Thielitz
Aug 30, 2008·Experimental Gerontology·Evgenia MakrantonakiChristos C Zouboulis
Nov 18, 2008·The Journal of Steroid Biochemistry and Molecular Biology·E CalvoF Labrie
Dec 17, 2008·The British Journal of Dermatology·R GancevicieneC C Zouboulis
May 15, 2009·Indian Journal of Dermatology, Venereology and Leprology·Balaji Adityan, Devinder Mohan Thappa
Aug 6, 2009·BMC Complementary and Alternative Medicine·Tamsyn S A ThringDeclan P Naughton
Oct 8, 2009·The Journal of Investigative Dermatology·Christos C Zouboulis
Mar 27, 2010·Experimental Dermatology·WenChieh ChenChristos C Zouboulis
Apr 23, 2010·The Journal of Investigative Dermatology·Bassel H MahmoudIltefat H Hamzavi
May 4, 2010·Dermato-endocrinology·Qiang JuLongqing Xia
May 26, 2010·Journal of the American Dietetic Association·Jaime UribarriHelen Vlassara
Jul 14, 2010·Clinics in Dermatology·Meagen M McCusker, Jane M Grant-Kels
Jul 29, 2010·The Journal of Investigative Dermatology·Andrea VierkötterJean Krutmann
Aug 4, 2010·Medical Hypotheses·V KahanS Tufik
Aug 12, 2010·The British Journal of Dermatology·M El-AlfyF Labrie
Aug 20, 2010·Experimental Gerontology·Evgenia MakrantonakiChristos C Zouboulis
Sep 3, 2010·Dermato-endocrinology·Renata Strumia
Dec 28, 2010·International Immunopharmacology·Vivek R YadavBharat B Aggarwal
Jan 22, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·X TangS Madronich

❮ Previous
Next ❯

Citations

Sep 3, 2020·Experimental Dermatology·Christos C ZouboulisMarlon R Schneider
Feb 15, 2021·Dermatology and Therapy·Jaime Piquero-CasalsGabriella Fabbrocini
Feb 25, 2021·Journal of Cosmetic Dermatology·Daniel Morgado-CarrascoJaime Piquero-Casals
May 6, 2021·Clinical and Translational Allergy·Guillem HuraultReiko J Tanaka
Apr 26, 2021·Photodermatology, Photoimmunology & Photomedicine·Jean KrutmannAkimichi Morita
Jun 3, 2021·International Journal of Molecular Sciences·Georgeta St BochevaAndrzej T Slominski
May 29, 2021·Pigment Cell & Melanoma Research·Hee Young KangMauro Picardo
Jun 3, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·T PasseronE M J Peters
May 18, 2021·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Ellen M S XerfanJane Tomimori

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.