Clinical and biological significance of CD56 antigen expression in acute promyelocytic leukemia

Leukemia & Lymphoma
Shigeki ItoKazunori Murai

Abstract

The biological significance of CD56 antigen expression in patients with acute promyelocytic leukemia (APL) has been under investigation. We investigated the clinical and biologic features of CD56+APL. In our series, CD56 antigen was positive in 4 of 28 (14%) APL patients. No differences were found regarding age, gender, performance status (PS), initial leukocyte and platelet counts, lactate dehydrogenase (LDH) and fibrinogen (Fbg) levels according to CD56 expression. CD34 antigen was co-expressed in 3 of the 4 patients with CD56+ APL, in contrast to 2 of the 24 patients with CD56- APL (P = .01). Extramedullary relapse occurred in 3 of the 4 patients with CD56+ APL, in contrast to none of the 24 patients with CD56- APL (P = .001). Median remission duration was 4 months in CD56+ APL and was not reached in CD56- APL. The CD56+ population had a shorter remission duration (P < .0001) and disease-free survival (P < .0001). In contrast, no difference was found in overall survival. These results suggested that CD56 expression was associated with the leukemogenetic mutation at the primitive hematopoietic progenitor cell level and extramedullary relapse in APL patients treated with ATRA and chemotherapy.

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Citations

Dec 27, 2011·Frontiers of Medicine·Jianqing Mi
Jan 30, 2010·International Journal of Hematology·Ritsuro SuzukiTomoki Naoe
Feb 21, 2008·Acta Haematologica·Elpis MantadakisMaria Kalmanti
Jun 19, 2014·International Journal of Hematology·Junmin LiZhenyi Wang
Jul 18, 2015·American Journal of Clinical Pathology·Thomas M MaenhoutDries Deeren
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May 29, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Satoshi YoshiharaHiroyasu Ogawa
Mar 16, 2018·Oncology Letters·Can ChenShenxian Qian

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